Table of Contents
Which of the following is used in the synthesis of benzofuran?
A convenient metal-free cyclization of ortho-hydroxystilbenes into 2-arylbenzofurans and 2-arylnaphthofurans is mediated by hypervalent iodine reagents. Using stoichiometric (diacetoxyiodo)benzene in acetonitrile, desired products can be isolated in good yields.
How do you make benzofuran?
Benzofurans can be prepared by various methods in the laboratory. Notable examples include: O-alkylation of salicylaldehyde with chloroacetic acid followed by dehydration (cyclication) of the resulting ether and decarboxylation.
What are coumarin derivatives?
Coumarin derivatives (4-hydroxycoumarin compounds) are oral anticoagulants (OA) that prevent vitamin K from acting as a cofactor in the hepatic synthesis of the vitamin K-dependent coagulation factors II, VII, IX, and X (as well as the anticoagulants, proteins C and S).
Which drug contain pyrrole nucleus?
Three drugs that contain a pyrrole ring are Atorvastatin, Tolmetin, and Atorolac.
What is indole synthesis?
Indole can still be synthesized, however, using the Fischer indole synthesis by reacting phenylhydrazine with pyruvic acid followed by decarboxylation of the formed indole-2-carboxylic acid. This has also been accomplished in a one-pot synthesis using microwave irradiation.
Which is used for synthesis of coumarin?
The Pechmann method has been used for the synthesis of coumarin derivatives in the presence of FeCl3·6H2O [101]. The feasibility of iron salt catalysts were observed in condensation reaction of resorcinol and methyl acetoacetate.
What is coumarin made of?
Coumarins are phenolic substances composed of fused benzene and α-pyrone rings. At least 1300 different coumarins have been identified. Coumarins have antithrombotic, antiinflammatory, and vasodilatory activities. Warfarin is the most popular one and it is used as an oral coagulant and rodenticide.
What is coumarin made from?
Coumarin, or is 1,2-benzopyrone, occurs naturally in tonka beans and cinnamon, but can also be found in trace amounts in bison grass, green tea, carrots, and even some beers.
What is the best way to synthesize benzofurans?
A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate yields. The utility of the method is further demonstrated by the synthesis of the natural product eupomatenoid 6 in three steps. C. Eidamshaus, J. D. Burch, Org.
What are the one-pot reactions for the synthesis of benzofurans?
One-pot reactions of acyl chlorides, phosphorus ylides, and o-iodophenols in the presence of a copper catalyst enable a rapid synthesis of functionalized benzofurans. Y. Liu, H. Wang, J.-P. Wan, J. Org. Chem., 2014, 79, 10599-10604.
What are benzofuran derivatives?
Benzofuran derivatives are an important class of heterocyclic compounds that are known to possess interesting biological properties. Compounds of this type find wide application in many fields of chemistry and agriculture. Therefore the development of simple, fast and flexible syntheses remains a challenge for organic chemists.
Is hydroxyterphenylphosphine an effective ligand for benzo [b]furan synthesis?
Hydroxyterphenylphosphine is an effective ligand for a Pd-catalized one-pot benzo [ b ]furan synthesis from 2-chlorophenols and alkynes. J.-R. Wang, K. Manabe, J. Org. Chem., 2010 , 75, 5340-5342.