Table of Contents
Do urology reflux have a genetic component?
Family history. Primary vesicoureteral reflux tends to run in families. Children whose parents had the condition are at higher risk of developing it. Siblings of children who have the condition also are at higher risk, so your doctor may recommend screening for siblings of a child with primary vesicoureteral reflux.
What is Urology reflux?
Urinary reflux means that one (or both) of these valves is not working properly. If you have urinary reflux, during urination the urine travels up the affected ureter to the kidney instead of flowing out of the body. Urinary reflux most commonly occurs in babies and children.
Is vesicoureteral reflux congenital?
Vesicoureteral reflux (VUR) is the retrograde flow of urine from the bladder into the upper urinary tract and it is the most common urological anomaly in children. Primary VUR is a congenital condition caused by the abnormal development and malfunction of the ureterovesical junction (UVJ).
What is the medical definition for vesicoureteral reflux?
Vesicoureteral reflux (VUR) is a condition in which urine flows backward from the bladder to one or both ureters and sometimes to the kidneys. VUR is most common in infants and young children. Most children don’t have long-term problems from VUR.
Is VUR inherited?
It is clear that in a large proportion of patients VUR is genetic in origin. Forty five percent of children with primary VUR are from families where at least one additional family member is affected, and often the disease occurs in two or more generations (10,14).
Is VUR a birth defect?
Causes & Risk Factors In most children, VUR is a birth defect caused by an unusual attachment between the ureter tube and the bladder. This is known as primary VUR and it is the most common type. Primary VUR often affects only one ureter and one kidney but can affect both kidneys.
How is urinary reflux treated?
Treatment may include:
- Surgery to remove a blockage or correct an abnormal bladder or ureter.
- Antibiotics to prevent or treat a UTI.
- Intermittent catheterization (draining the bladder of urine by inserting a thin tube, called a catheter, through the urethra to the bladder).
- Bladder muscle medication.
How do you test for urinary reflux?
Reflux is found with a test called a voiding cystourethrogram (VCUG), which is an X-ray of the bladder. It takes about 15 to 20 minutes, and involves: Placing a catheter (a thin plastic tube) in the urethra. Injecting fluid with an X-ray dye through the tube until the bladder is full.
What causes urinary reflux?
Urinary reflux is when urine flows backward from the bladder into the ureter and sometimes the kidney, usually because of a birth defect of the urinary tract.
What causes kidney reflux?
What causes reflux? In the human urinary tract there is a valve where the bladder joins the urine tube, or ureter, that comes from the kidney. Some children are born with a problem valve that does not close properly, so the urine refluxes back into the kidney.
How is urinary reflux diagnosed?
Reflux is diagnosed using an x-ray called a voiding cystourethrogram (VCUG), or a nuclear cystogram. Both tests involve a urinary catheter (tube) placed into the child’s bladder to fill the bladder with x-ray dye or radioactive material.
What is urology genetics&genomics?
Urology Genetics & Genomics. It includes studies seeking to elucidate the heritability or molecular genetic basis of single-gene or genetically complex familial diseases in humans. This work includes studies that identify and characterize quantitative trait loci or modifier loci affecting single-gene traits in humans or animal models.
Is acid reflux hereditary?
If acid reflux is genetic, this means that multiple family members are more likely to have the condition. Research at the University of Amsterdam found a pattern of inheritance of GERD among multi-generational family members. Of the 28 family members who participated in the study, 17 members from four generations were affected with GERD.
Does GERD have a genetic basis?
The researchers concluded that GERD has a genetic basis, and they hypothesized that all three diseases are linked to the same gene locus. Many other studies have shown a link between genetics and GERD.
What is acid reflux disease (GERD)?
This chronic form of acid reflux is called gastroesophageal reflux disease (GERD). GERD is more serious and can lead to serious health problems if not treated. Symptoms of GERD occur more than twice a week and include: What Causes Acid Reflux?