Table of Contents
What is hemoglobin D disease?
Hemoglobin D trait (AD) is an inherited condition which affects the hemoglobin in your red blood cells. • Hemoglobin is a protein in red blood cells. The job of hemoglobin is to carry oxygen through the body.
What are the two variants of hemoglobin D?
The names Hb D Los Angeles and Hb D Punjab are used to describe this variant, with the former name used more often in North America and the latter in the United Kingdom. Hb D Punjab is found in the Punjab region of the Indian subcontinent, especially in Sikhs from the Lycus Valley.
Is hemoglobin A thalassemia D?
Hemoglobin D/beta thalassemia happens when the part of the red blood cell that carries oxygen throughout the body is changed. This part that is changed is called hemoglobin. Hemoglobin is important because it picks up oxygen in the lungs and carries it to the other parts of the body.
What is hemoglobin D carrier?
Your genes also control the type of haemoglobin you inherit. The usual type is called ‘A’. You have inherited the usual haemoglobin A from one of your parents, and a gene that makes unusual haemoglobin (in your case haemoglobin D) from the other parent. We call this being a haemoglobin D carrier.
How common is hemoglobin D?
Hemoglobin D disease is rare and usually does not cause serious health problems. If both parents have hemoglobin D trait, there is a chance of having a child with hemoglobin D disease. These are the possible outcomes with each pregnancy.
What is Hb D Punjab heterozygous?
Hemoglobin D-Punjab can be inherited in heterozygosis with hemoglobin A causing no clinical or hematological alterations, or in homozygosis, the rarest form of inheritance, a condition that is commonly not related to clinical symptomatology.
What is Hb D Punjab in pregnancy?
Hb D disease (homozygous form) is a rare disease and usually presents with mild haemolytic anaemia and mild to moderate splenomegaly. Case of a pregnant patient diagnosed incidentally with Hb D trait in her antenatal period posted for elective lower segment caesarean section has been reported.
Is hemoglobin D sickle cell?
Hemoglobin D disease is not a form of sickle cell disease. People who have hemoglobin D disease have red blood cells that contain mostly hemoglobin D. Too much hemoglobin D can reduce the number and size of red blood cells in your body, causing mild anemia.
Is thalassemia minor and carrier the same?
If you’re a carrier of thalassaemia, it means you carry one of the faulty genes that cause thalassaemia, but you do not have thalassaemia yourself. Being a carrier of the trait is sometimes known as having the thalassaemia trait or having thalassaemia minor.
What is d meaning of SC genotype?
The hemoglobin (Hb) SC genotype is seen in persons who have inherited the gene for hemoglobin S from one parent and the gene for hemoglobin C from the other. Some people with this genotype develop Hb SC disease, a variant of sickle cell disease.