Table of Contents
What does miR-122 do?
miR-122 regulates the synthesis of the protein CAT-1 by binding to sites in the mRNA 3’UTR such that translation is repressed and the mRNA is targeted to P bodies. This repression can be relieved by the protein HuR, which is released from the nucleus under conditions of cell stress and binds to the CAT-1 3’UTR.
What is micro RNA 122?
miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication.
What is miR-122 5p?
MiR-122-5p regulated the expression of proteins associated with cell cycle and apoptosis as well as migration and invasion. a, b The expression levels associated with cell cycle and apoptosis were determined in PDAC cells using qRT-PCR and western blot after transfection with miR-122-5p mimics.
What is the function of MicroRNA?
microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization.
How do MicroRNA work?
miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3′-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational silencing.
Which microRNA miR-122 controls systemic iron homeostasis in mice?
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest. 2011;121:1386–96. doi: 10.1172/JCI44883.
What causes microRNA miR-122 levels to decrease in hepatitis C patients?
“Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy”. Nature Medicine. 15 (1): 31–33. doi: 10.1038/nm.1902. PMID 19122656. S2CID 32303418. ^ Ruoquan Y (February 2014). “Correlation between plasma miR-122 expression and liver injury induced by hepatectomy”.
Does microRNA-122 release during liver preservation during transplantation?
“The release of microRNA-122 during liver preservation is associated with early allograft dysfunction and graft survival after transplantation”. Liver Transplantation. 23 (7): 946–956. doi: 10.1002/lt.24766.
Is microRNA-122 a useful biomarker for viral hepatitis?
“Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases”. Clin Chem. 56 (12): 1830–1838. doi: 10.1373/clinchem.2010.147850.