Table of Contents
What is the shape of Flavivirus?
This chapter focuses on Flaviviridae family, whose member genuses are Flavivirus, Pestivirus, and Hepacivirus. The virions are 40–60 nm in diameter, spherical in shape, and contain a lipid envelope. The capsid is composed of a single protein and the envelope contains two or three virus-encoded membrane proteins.
What is Flavivirus made of?
Nucleocapsid. The flavivirus particle consists of an electron-dense inner core called the nucleocapsid (NC). The NC complex contains multiple copies of the C protein and a single copy of genomic RNA, and the production of infectious virus particles requires the NC.
Why is it called the Flavivirus?
Flaviviruses are named for the yellow fever virus; the word flavus means ‘yellow’ in Latin, and yellow fever in turn is named from its propensity to cause yellow jaundice in victims.
How big is the flavivirus?
Flaviviruses have enveloped and spherical virions (virus particles) that are between 40 and 60 nm (1 nm = 10−9 metre) in diameter. The flavivirus genome consists of nonsegmented single-stranded positive-sense RNA (ribonucleic acid). Flaviviridae contains three genera: Flavivirus, Hepacivirus, and Pestivirus.
What is the life cycle of flavivirus?
Flavivirus particles undergo major conformational changes during the life cycle. Some of these changes can be inferred from structural information available for the immature and mature virions as well as the pre-fusion dimer and the post-fusion trimer21,24,25,26,40,71,72,84,85. Virus maturation is a two-step process.
What is the life cycle of Flavivirus?
Is Flavivirus a DNA or RNA virus?
The Flaviviridae are a family of positive, single-stranded, enveloped RNA viruses. They are found in arthropods, (primarily ticks and mosquitoes), and can occasionally infect humans. Members of this family belong to a single genus, Flavivirus, and cause widespread morbidity and mortality throughout the world.
Who discovered Flavivirus?
Sir Walter Reed (1851-1902) discovers the first virus when he conclusively demonstrates that yellow-fever is transmitted by the bite of the mosquito Aëdes aegypti. Sir Walter experimentally transfers the disease via filtered serum of one infected individual to another healthy individual.
How does Flavivirus reproduce?
Replication of Flaviviruses takes place in the cytoplasm. Flavivirus cannot replicate in the nucleus because, like most other RNA viruses, it uses the host cell’s RNA dependant RNA polymerase to replicate. Primarily, the virus will make a full length copy of the complementary, minus strand genome.
How does Flavivirus cause yellow fever?
Yellow fever virus is an RNA virus that belongs to the genus Flavivirus. It is related to West Nile, St. Louis encephalitis, and Japanese encephalitis viruses. Yellow fever virus is transmitted to people primarily through the bite of infected Aedes or Haemagogus species mosquitoes.
Is chikungunya a Flavivirus?
Introduction. Chikungunya virus (CHIKV) and Zika virus (ZIKV) are arthropod-borne viruses (arboviruses) transmitted by mosquitoes. Based on the most current taxonomy of viruses, CHIKV and ZIKV belong to the Togaviridae family and the Flaviviridae family, respectively.
What is the protein coat of a virus called?
the capsid
A virus is made up of genetic material that is encased with a protective protein coat called the capsid.