Table of Contents
What is VDR mutation?
Vitamin D-dependent rickets The VDR gene mutations that cause this condition prevent the VDR protein from functioning properly. Some changes in the VDR gene lead to an abnormally short version of the VDR protein. Others result in the production of an abnormal receptor that cannot bind to calcitriol, to RXR, or to DNA.
What is VDR expression?
VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals. Glucocorticoids decrease VDR expression. Many types of immune cells also express VDR.
Where are VDR found?
human skeletal muscle cells
Vitamin D receptor (VDR) has been found in human skeletal muscle cells, where it affects muscle cell metabolism by binding to vitamin D metabolites. The VDR is involved in sustaining normocalcemia by inhibiting the production of parathyroid hormone and has effects on bone and skeletal muscle biology.
How is VDR mutation treated?
Successful treatment requires reversal of hypocalcemia and secondary hyperparathyroidism and is usually accomplished by administration of high doses of calcium given either intravenously or sometimes orally to bypass the intestinal defect in VDR signaling.
Under what condition is VDR used?
A VDR is capable of withstanding heavy weather, collisions, fires and pressure conditions even when a ship is at a depth of several meters in water.
Does vitamin D increase VDR?
The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass.
How does vitamin D increase calcium absorption?
1,25(OH)2D increases calcium absorption by binding to the vitamin D receptor in the intestine (3). Optimal calcium intake is essential for mineralization of bone and plays a role in the prevention of osteoporosis and fractures among the elderly population.
Which vitamin is antagonist of vitamin D?
6-Fluoro-vitamin D3: a new antagonist of the biological actions of vitamin D3 and its metabolites which interacts with the intestinal receptor for 1 alpha,25(OH)2-vitamin D3.
What is the difference between S VDR and VDR?
S-VDR. The SVDR is nothing but a simplified VDR, that records information that is only absolutely necessary and does not record information as extensive as the VDR. Naturally, it is more cost effective and more in usage on board merchant ships.
What is the importance of VDR?
The primary purpose of a voyage data recorder (VDR) or a simplified voyage data recorder (S-VDR) is to maintain a store of information in a secure and retrievable form, concerning the position, movement, physical status, command and control of a vessel over the period leading up to and following an incident.
How does vitamin D influence VDR expression?
Does vitamin d3 raise calcium levels?
Along with the aforementioned reasons, taking a vitamin D supplement over an extended period of time can cause the blood calcium level to rise.
Does vitamin D Reduce Magnesium?
Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.