Are Myogenin and MyoD1 expression specific for rhabdomyosarcoma?
… Myogenin, MyoD1, and myoglobin are markers specific to striated muscle. Myogenin is highly sensitive and specific for rhabdomyosarcoma and is useful for differential diagnosis [24] .
What is desmin sarcomere?
Desmin connects the Z-discs to one another, linking neighboring sarcomeres and forming myofibrils, the basic unit of muscle fibers. The connection of sarcomeres to each other to form myofibrils is essential for maintaining muscle fiber strength during repeated cycles of contraction and relaxation.
Are myogenin and MyoD1 specific IHC markers for human RMS in veterinary oncology?
Myogenin and MyoD1 are transcription factors reported to be sensitive and specific IHC markers for human RMS, but they are not widely used in veterinary oncology. The goals of this study were to develop an IHC protocol for myogenin and MyoD1, evaluate myogenin and MyoD1 labeling in canine RMS, and report clinical outcomes.
What are myo-d1 myogenin and MRF4?
Myo-D1, myogenin, MRF4 (also called herculin or myf-6) and myf-5 are members of the Myo-D family of transcription factors and are responsible for initiating striated muscle differentiation. Myf-5 and MRF4 are expressed at specific limited periods in myogenesis. MyoD1 and myogenin are downregulated at birth.
What is the difference between myogenin and my-d1 staining?
Staining with My-D1 may become weaker if sections are stored for a few days after cutting2. Staining for both antigens is lost with mercury-based fixatives such as B52. Staining is strictly nuclear. Myogenin produces staining that is clearly localised to the nucleus.
Which lymph nodes are myogenin positive in rhabdomyosarcoma?
Immunohistochemical expression skeletal muscle lymph nodes may show rare myogenin-positive benign nuclei2. Myogenin has been detected in: strongly expressed in alveolar rhabdomyosarcoma and to a lesser extent in other rhabdomyosarcomas.