Does docetaxel need to be refrigerated?

Does docetaxel need to be refrigerated?

Docetaxel vials should be stored between 2 and 25°C (36 and 77°F). If the vials are stored under refrigeration, allow the appropriate number of vials of Docetaxel Injection Concentrate vials to stand at room temperature for approximately 5 minutes before use.

Does docetaxel need to be protected from light?

Docetaxel injection concentrate (Hospira): Store unopened vials at 20–25°C in original package to protect from light. Store multiple-dose vials at 2–8°C between uses, protected from light, for up to 28 days.

When do you hold docetaxel?

5.4 Hypersensitivity Reactions Severe hypersensitivity reactions require immediate discontinuation of the Docetaxel Injection infusion and aggressive therapy. Patients with a history of severe hypersensitivity reactions should not be rechallenged with Docetaxel Injection.

How long is docetaxel administered?

For locally advanced or metastatic breast cancer after failure of prior chemotherapy, the recommended dose of TAXOTERE is 60 mg/m2 to 100 mg/m2 administered intravenously over 1 hour every 3 weeks….

TAXOTERE® Prescribing Information
(docetaxel) injection, for intravenous use Rx only

How do you dissolve a docetaxel?

For maximum solubility in aqueous buffers, docetaxel (hydrate) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Docetaxel (hydrate) has a solubility of approximately 0.1 mg/ml in a 1:10 solution of DMSO:PBS (pH 7.2) using this method.

How is Taxotere administered?

Taxotere is given through a vein (intravenously, IV) There is no pill form of Taxotere. Premedication with a corticosteroid pill starting a day prior to Taxotere infusion for 3 days is given to reduce the severity of fluid retention and allergic reactions. Your doctor will prescribe the exact regimen.

Does cold cap work with docetaxel?

The cold cap is a very effective technique with minimal side-effects for docetaxel-treated patients.

How do you store light sensitive drugs?

Store the vial in the original carton to protect from light. Keep ampules in package until time of use. Drug can be stored in a syringe for up to 8 hours prior to administration but must be protected from direct sunlight. Store in the original carton to protect from light.

Why is dexamethasone used with docetaxel?

Abstract. Background: The administration of docetaxel requires the use of dexamethasone for the prevention of hypersensitivity reactions (HSRs) and fluid retention reactions (FRRs). The manufacturer recommends dexamethasone for 3 days starting the day before docetaxel.

Can docetaxel cause fever?

Fever on posttreatment days 3 and 4 was most commonly observed in patients treated with gemcitabine (20 %) or docetaxel (18 %). The causes of fever included infection (47 %; including febrile neutropenia [24 %]), adverse drug effects (24 %), unknown causes (19 %), and tumors (7 %).

Is docetaxel water soluble?

Docetaxel is a white to off-white powder, synthesised in the anhydrous form. At 25ºC docetaxel is freely soluble in ethanol and tetrahydrofuran; sparingly soluble in acetonitrile; soluble in methanol, acetone and ethyl acetate; insoluble in n-hexane and water.

How is docetaxel made?

Docetaxel belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The taxanes are made from the bark of the Pacific Yew tree (taxus).

How cold is the Paxman cold cap?

Q: How cold does it get? The cooling system brings the scalp temperature to roughly 66 degrees Fahrenheit (20 degrees Celsius).

Are cold caps effective?

Of those who wore a cap consistently cooled to 32 degrees for 30 minutes before their chemotherapy treatment, throughout every chemo session, and for 90 to 120 minutes afterward, 66 percent experienced hair loss of 50 percent or less.

At what temperature should medication be stored?

All medicine comes with label instructions regarding safe storage. Most medicines should be stored at 59 to 77 degrees °F in a cool, dry place. That degree range is important. The chemicals and components of some drugs can be changed when exposed to different temperatures.

What temperature should non refrigerated drugs be stored at?

General Temperature Control For most oral medications, manufacturers guarantee efficacy when medicine is stored at 68 to 77 degrees, but 58 to 86 degrees is usually fine, says Philip Chan, a pharmacist at the University of California, San Francisco, School of Pharmacy.

What is the half life of docetaxel?

Docetaxel’s pharmacokinetic profile is consistent with a three-compartment pharmacokinetic model, with half-lives for the α, β, and γ phases of 4 min, 36 min, and 11.1 hr, respectively.

Why does docetaxel cause fluid retention?

Docetaxel therapy frequently triggers fluid retention presenting as swelling of the extremities, pleural effusions, ascites, and pericardial effusion. One of the proposed mechanisms underlying this adverse effect is increased permeability of the capillaries resulting in leakage of fluid into the surrounding tissue.

What is a high temperature on chemotherapy?

Call your doctor if you have a temperature of 100.4ºF (38ºC) or higher. If you get a fever during your chemotherapy treatment, it’s a medical emergency. Fever may be the only sign that you have an infection, and an infection during chemotherapy can be life-threatening.

Can chemo cause high temperature?

Fever is a possible side effect of both chemotherapy and biologic treatments. Fever is normally the body’s response to infection. Experiencing a fever during chemotherapy requires immediate treatment. Chemotherapy causes a low white blood cell count in the blood.

Do docetaxel vials need to be refrigerated?

Docetaxel vials should be stored between 2 and 25°C (36 and 77°F). If the vials are stored under refrigeration, allow the appropriate number of vials of Docetaxel Injection Concentrate vials to stand at room temperature for approximately 5 minutes before use.

What is the strength of docetaxel in one vial?

The following strengths are available in a one-vial formulation: Docetaxel Injection, USP 20 mg/2 mL (10 mg/mL) single-dose vials in cartons containing 1 vial each (NDC 70700-174-22) Docetaxel Injection, USP 80 mg/8 mL (10 mg/mL) multiple-dose vials in cartons containing 1 vial each (NDC 70700-175-22)

What are the side effects of docetaxel?

PATIENT INFORMATION 1 The chance of death in people who receive Docetaxel injection is higher if you: 2 Docetaxel injection can affect your blood cells. 3 Severe allergic reactions can happen in people who received Docetaxel injection. 4 Your body may hold too much fluid (severe fluid retention) during treatment with Docetaxel…

When to adjust the dose of docetaxel?

Patients who are dosed initially at 100 mg/m2and who experience either febrile neutropenia, neutrophils <500 cells/mm3for more than 1 week, or severe or cumulative cutaneous reactions during Docetaxel injection therapy should have the dosage adjusted from 100 mg/m2to 75 mg/m2.