Table of Contents
What are the Premeds for docetaxel?
For prostate cancer, given the concurrent use of prednisone or prednisolone the recommended premedication regimen is oral dexamethasone 8 mg, 12 hours, 3 hours and 1 hour before the docetaxel infusion (see section 4.4). Docetaxel is administered as a one-hour infusion every three weeks.
Why is dexamethasone given prior to docetaxel?
Objectives: Dexamethasone is commonly used to prevent the adverse effects of docetaxel in head and neck neoplasm treatment. The recommended dexamethasone dose is 8 mg orally twice daily for 3 days for each injection of docetaxel. This pre-medication reduces the incidence of adverse effects to 1-2% of treated patients.
Why is dexamethasone given with Taxotere?
A small number of people who take Taxotere have severe fluid retention, which can be life- threatening. To help avoid this problem, you must take another medication such as dexamethasone (DECKS-A-METH-A-SONE) prior to each Taxotere treatment.
Which of the following medications is administered prior to docetaxel to reduce the risk of hypersensitivity?
Pre- and post-treatment administration of dexamethasone is recommended to decrease the frequency and severity of fluid retention and hypersensitivity reactions. 1 Premedication with 3 doses of dexamethasone prior to each docetaxel infusion is a standard for both the 3-weekly and weekly docetaxel regimens.
Why is dexamethasone given prior to plant alkaloids?
Background: The administration of docetaxel requires the use of dexamethasone for the prevention of hypersensitivity reactions (HSRs) and fluid retention reactions (FRRs). The manufacturer recommends dexamethasone for 3 days starting the day before docetaxel.
How do I administer docetaxel?
The recommended dose of Docetaxel Injection is 75 mg/m2 administered intravenously over 1 hour immediately followed by cisplatin 75 mg/m2 over 30-60 minutes every 3 weeks [see Dosage and Administration (2.7)].
What happens if I forgot to take dexamethasone before chemo?
you understand the directions. If you miss a dose or vomit within one hour of taking dexamethasone, take it as soon as you can. Call your doctor (during office hours) to ask about when to take your next dose.
What can you eat on docetaxel?
Your oncology care team can recommend medications to relieve diarrhea. Also, try eating low-fiber, bland foods, such as white rice and boiled or baked chicken. Avoid raw fruits, vegetables, whole grain bread, cereals, and seeds. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea.
How many doses of docetaxel can you have?
The recommended dose of docetaxel is 75 mg/m2 every 3 weeks for 6 cycles. Prednisone or prednisolone 5 mg orally twice daily may be administered continuously.
Why do they give dexamethasone with chemotherapy?
Background: Dexamethasone is a steroid, which is often given into the vein before chemotherapy to help control acute nausea and vomiting. It can also be given as an oral tablet for patients to take for the two days following chemotherapy to help minimise delayed nausea and vomiting.
What are the pre meds before chemotherapy?
Premedication before chemotherapy for cancer often consists of drug regimens (usually 2 or more drugs, e.g. dexamethasone, diphenhydramine and omeprazole) given to a patient minutes to hours before the chemotherapy to avert side effects or hypersensitivity reactions (i.e. allergic reactions).
What medication do you take before chemotherapy?
Corticosteroids, such as dexamethasone and methylprednisolone. Monoamine antagonists, such as olanzapine. Serotonin antagonists, such as dolasetron, granisetron. Substance P/NK1 Antagonists, including aprepitant, fosaprepitant and others.
How is docetaxel administered?
Docetaxel is given through a vein (intravenously, IV) Premedication with a corticosteroid pill starting a day prior to docetaxel infusion for 3 days is given to reduce the severity of fluid retention and allergic reactions. Your doctor will prescribe the exact regimen.
How often do you give docetaxel for prostate cancer?
For hormone-refractory metastatic prostate cancer, the recommended dose of Docetaxel injection is 75 mg/m2every 3 weeks as a 1 hour intravenous infusion. Prednisone 5 mg orally twice daily is administered continuously [see Dosage and Administration (2.7)].
How much prednisone do you give for docetaxel?
75 mg/m2 IV over 1 hour every 21 days plus prednisone (5 mg orally twice daily) for 10 cycles. All patients should be pre-medicated with corticosteroids prior to docetaxel infusion to reduce the incidence and severity of fluid retention as well as the severity of hypersensitivity reactions.
What is the pharmacokinetics of docetaxel in cancer patients?
The pharmacokinetics of Docetaxel have been evaluated in cancer patients after administration of 20 mg/m 2 to 115 mg/m 2 in phase 1 studies. The area under the curve (AUC) was dose proportional following doses of 70 mg/m 2 to 115 mg/m 2 with infusion times of 1 to 2 hours.