What do SH2 domains bind?
Abstract. Src homology 2 (SH2) domains are protein modules (of approximately 100 amino acids) found in many proteins involved in tyrosine kinase signalling cascades. Their function is to bind tyrosine-phosphorylated sequences in specific protein targets.
Does Jak2 P have a SH2 domain?
The Jak2 SH2 domain is colored blue. The phosphotyrosine sidechain and selected residues in the binding pocket are shown in stick form. Note that Phe436 in the Jak2 SH2 domain blocks the position that would be occupied by the phenyl group of a bound phosphotyrosine.
Does PI 3 kinase have a SH2 domain?
The phosphoinositide 3-kinase (PI3K) is frequently activated in human cancer cells due to gain of function mutations in the catalytic (p110) and the regulatory (p85) subunits. The regulatory subunit consists of an SH3 domain and two SH2 domains.
Which of the following proteins has an SH2 domain?
SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways….SH2 domain.
| Available protein structures: | |
|---|---|
| PDBsum | structure summary |
What is SH1 domain?
The SH1 domain is the catalytic domain. The crystal structure of the Src-family tyrosine kinase hck has been solved [7]. Its catalytic (SH1) domain has an overall bilobal structure, with a small ATP-binding N-terminal lobe and a large peptide-binding C-terminal lobe.
How many domains are there in JAK2?
JAK2 is associated with the cytoplasmic region of a cytokine receptor (gray). The four domains of JAK2 are labeled “F” for FERM, “S” for SH2L, “2” for JH2, and “1” for JH1.
Where is the SH2 domain?
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins.
What does SH2 stand for?
Src Homology 2
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins.
What is an SH2 domain and what role does it play in signaling pathways?
SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. SH2 domains are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.
What chromosome is JAK2 on?
Chromosome 9
Janus kinase 2
| Gene location (Human) | ||
|---|---|---|
| Chr. | Chromosome 9 (human) | |
| Band | 9p24.1 | Start |
| End |
What do Sh3 domains bind?
The SH3 domain is a distinct motif that binds target proteins, including proteins associated with the actin cytoskeleton, through sequences containing proline and hydrophobic amino acids.
What role do the Sh2 and Sh3 domains play in the function of GRB2?
What role do Sh2 and Sh3 domains play in the function of GRB2? GRB2 is an adaptor protein. It contains one Sh2 domain, and two Sh3 domains on the N terminal and C terminal ends. Sh3 directs the binding of proline rich proteins of other compounds, and Sh2 directs the binding of tyrosine phosphorylated sequences.
What determines the specificity of SH2 interactions with other molecules?
The target specificity of individual SH2 domains is based on the recognition of the three amino acids carboxyl terminal to the phospho-tyrosine within the target molecule.