Table of Contents
What is the solubility of carbamazepine?
Carbamazepine solubility in water is about 125 mg/L.
Is glipizide soluble in water?
Glipizide is poorly water soluble (BCS class II) antidiabetic drug. Due to poor solubility of drug, its bioavailability rate is limited by drug dissolution.
How do you use Hansen solubility parameters?
2.1 Hansen solubility parameter It gives a simple analogy of solubility in terms of relativeness, and it follows as RED = Ra/R0: if RED <1. the two materials will dissolve; if RED = 1, materials dissolve partially; and if RED >1, two materials do not dissolve.
Is carbamazepine soluble in water?
A problem facing the delivery of carbamazepine is its poor water solubility (<200 μg/mL), which generally results in a slow and irregular absorption (5).
Is carbamazepine soluble in ethanol?
Carbamazepine is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of carbamazepine in ethanol is approximately 3 mg/ml and approximately 25 mg/ml in DMSO and DMF. Carbamazepine is sparingly soluble in aqueous buffers.
How is glipizide excreted?
Glipizide is mainly eliminated by hepatic biotransformation, where less than 10% of the initial dose of the drug can be detected in the urine and feces as unchanged glipizide. About 80% of the metabolites of glipizide is excreted in the urine while 10% is excreted in the feces.
Does Glipizide have a black box warning?
SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR MORTALITY The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin.
Is gabapentin water soluble?
Gabapentin is a white to off-white crystalline solid with a pKa1 of 3.7 and a pKa2 of 10.7. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is –1.25.
Is carbamazepine acidic or basic?
Carbamazepine is an extremely weak basic (essentially neutral) compound (based on its pKa). Within humans, carbamazepine participates in a number of enzymatic reactions.
Can you crush glipizide?
Swallow the extended release tablet whole. Do not split, crush, or chew it. If you are taking the extended release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine.
Is glipizide being discontinued?
Glipizide/Metformin is only available as a generic drug; all brands have been discontinued.
What 2 factors directly affect solubility?
Solubility is the maximum amount of a substance that will dissolve in a given amount of solvent at a specific temperature. There are two direct factors that affect solubility: temperature and pressure.