How does HSP affect the kidneys?
In about half of children with HSP, the kidneys are affected. The tiny blood vessels in the kidneys, which filter blood to remove extra water, salt and waste into the urine, become inflamed. This causes the kidneys to ‘leak’ blood cells and proteins into urine. This is sometimes called HSP nephritis.
Does Henoch-Schönlein purpura cause nephrotic syndrome?
Henoch-Schönlein purpura (HSP) is the one of most common types of systemic vasculitis in childhood. Glomerulonephritis (HSPN) occurs in 30-50 % of HSP patients, mostly in a mild form but a small percentage of patients present with nephrotic syndrome or renal failure.
Is HSP IgA nephropathy?
Henoch–Schönlein purpura (HSP) is a small vessel systemic vasculitis characterized by small blood vessel deposition of IgA that predominantly affects the skin, joints, gut, and kidney, with nephritis that may be histologically indistinguishable from IgA nephropathy.
What is the pathophysiology of Henoch-Schönlein purpura?
The pathophysiology of Henoch-Schönlein purpura is not fully understood; however, IgA plays a significant role. IgA-antibody immune complexes caused by antigenic exposure from an infection or medication deposit in the small vessels (usually capillaries) of the skin, joints, kidneys, and gastrointestinal tract.
How does IgA vasculitis affect the kidneys?
Kidney involvement. In IgA vasculitis, the unusual activity of the immune system causes inflammation, which can lead to kidney damage. You may need to take a corticosteroid or other immunosuppressive medicine to reduce the inflammation, which can help prevent your immune system from causing more damage.
Can renal failure cause purpura?
In another form, known as Henoch’s purpura, affected individuals have purplish spots on the skin and acute abdominal problems, such as glomerulonephritis (a type of kidney disorder).
What type of hypersensitivity reaction is Henoch-Schönlein purpura?
Hematologic and immunological characteristics of Henoch-Schönlein purpura in rat and rabbit models induced with ovalbumin based on type III hypersensitivity.
How does vasculitis cause kidney failure?
This causes swelling and damage to the capillaries (blood vessels). When the glomeruli can’t filter the blood, protein and blood leak into the urine, which can lead to loss of kidney function or kidney failure in severe cases.
What is IgA vasculitis nephritis?
In IgA vasculitis, the unusual activity of the immune system causes inflammation, which can lead to kidney damage. You may need to take a corticosteroid or other immunosuppressive medicine to reduce the inflammation, which can help prevent your immune system from causing more damage.
What is HSP in nephrology?
Henoch-Schönlein purpura (HSP) is the most common small vessel vasculitis in children and adolescents with high incidence of renal involvement. Delayed and inappropriate management of severe Henoch-Schönlein nephritis is a major cause of chronic kidney disease.
Is IgA nephropathy and IgA vasculitis the same?
IgA nephropathy almost exclusively involves young adults and typically affects only the kidneys, whereas IgAV affects mostly children and involves the skin and connective tissues, GI tract, joints, and scrotum, as well as the kidneys.
What is the most common primary symptom of Schönlein Henoch purpura?
Causes and Risk Factors for Henoch-Schonlein Purpura The main symptom is a rash with numerous small bruises, which have a raised appearance, over the legs or buttocks. Other symptoms can include joint and abdominal pain as well as kidney impairment. HSP most commonly occurs in children and in boys more than girls.
What are the signs and symptoms of Henoch-Schönlein Purpura IgA vasculitis )?
Symptoms
- Rash (purpura). Reddish-purple spots that look like bruises develop on the buttocks, legs and feet.
- Swollen, sore joints (arthritis). People with Henoch-Schonlein purpura often have pain and swelling around the joints — mainly in the knees and ankles.
- Digestive tract symptoms.
- Kidney involvement.
Can vasculitis affect kidney function?
Kidneys: the specialised small blood vessels in the kidney which filter blood to make urine seem especially sensitive to vasculitis. The damage to the kidney can cause blood to appear in the urine as well as kidney failure in severe cases.
What is the long-term morbidity of Henoch-Schönlein purpura (HSP)?
The long-term morbidity of HSP is predominantly attributed to renal involvement. It is thus recommended that patients with HSP nephritis are followed for longer periods of time. Henoch-Schönlein purpura outcome in children: a ten-year clinical study.
Is there an association between Interleukin 8 and Henoch-Schönlein purpura?
HLA-DRB1*01 association with Henoch-Schönlein purpura in patients from northwest Spain. Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. Interleukin-1 beta gene polymorphism association with severe renal manifestations and renal sequelae in Henoch-Schönlein purpura.
What causes Henoch-Schönlein purpura nephritis (HSP)?
Henoch-Schönlein purpura nephritis associated with coagulase-negative staphylococci sepsis in a patient with myeloma. Galaria N.A. Henoch-Schönlein purpura secondary to subacute bacterial endocarditis.
Is Henoch-Schönlein purpura associated with clarithromycin?
Henoch-Schönlein purpura associated with clarithromycin. HLA-DRB1*01 association with Henoch-Schönlein purpura in patients from northwest Spain. Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis.