Table of Contents
What is situs inversus totalis?
Situs inversus totalis (SIT) is a rare congenital abnormality characterized by a mirror-image transposition of both the abdominal and the thoracic organs (Figure 1). This is a global defect of situs orientation, as the failure to generate normal left-right asymmetry results in a spectrum of laterality disturbances.
Is situs inversus totalis genetic?
A rare, genetic, developmental defect during embryogenesis characterized by total mirror-image transposition of both thoracic and abdominal viscera across the left-right axis of the body.
How rare is dextrocardia situs inversus totalis?
As it is recessive genes that cause dextrocardia, an individual must inherit a copy of the abnormal gene from both parents to develop the condition. Dextrocardia affects an estimated 1 out of every 12,000 people . Dextrocardia situs inversus totalis affects approximately 1 out of every 10,000 children.
How many cases are in situs inversus?
Situs inversus is found in about 0.01% of the population, or about 1 person in 10,000. In the most common situation, situs inversus totalis, it involves complete transposition (right to left reversal) of all of the viscera.
Is situs inversus totalis rare?
Situs inversus is a very rare condition. According to an article in the journal Heart Views , it occurs in an estimated 1 in 10,000 people.
What gene causes situs inversus?
A Homozygous Nme7 Mutation Is Associated with Situs Inversus Totalis.
Are people with situs inversus left-handed?
In a study of 88 people with PCD, only 15.2% of 46 individuals with situs inversus, and 14.3% of 42 individuals with situs solitus, were left handed.
What hand did Albert Einstein write with?
Handedness. There is a persistent popular belief that Einstein was left-handed, but there is no evidence that he was, and the belief has been called a myth. Einstein wrote with his right hand, and authoritative sources state flatly that he was right-handed.
Are left-handers intelligent?
Although data suggested that right-handed people had slightly higher IQ scores compared to left-handers, the scientists noted that intelligence differences between right and left-handed people were negligible overall.
Situs inversus totalis is a rare congenital abnormality characterized by a mirror-image transposition of both the abdominal and the thoracic organs. While this anomaly is known since the ancient times, practicing doctors do not have much experience with it.
What are the complications of situs inversus?
If a person with situs inversus does have complications like a heart defect, a doctor will treat the symptoms. Surgery to reverse the organs’ positioning is usually not recommended.
What are the surgical options for surgery in situs inversus?
Our experience with surgery in situs inversus: open peptic perforation repair and laparoscopic cholecystectomy in 1 patient and 3 patients respectively. Int J Surg Case Rep. 2016;29:34–38. doi:10.1016/j.ijscr.2016.10.035 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]
Is Situs Inversus an autosomal recessive disorder?
Situs inversus is generally an autosomal recessive genetic condition, although it can be X-linked or found in identical “mirror image” twins. About 25% of individuals with situs inversus have an underlying condition known as primary ciliary dyskinesia (PCD).