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What is systemic lupus erythematosus Pubmed?
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. Women of childbearing age and certain racial groups are typically predisposed to developing the condition.
What is systemic lupus erythematosus article?
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune rheumatic disease in which disease flares are interspersed with episodes of remission. In contrast to organ specific autoimmune diseases, SLE comprises a constellation of signs and symptoms that can affect multiple organ systems.
What is the classic presentation of systemic lupus erythematosus?
The patients with SLE may present with various systemic manifestations. The general symptoms include: fever, malaise, arthralgias, myalgias, headache, and loss of appetite and weight. Nonspecific fatigue, fever, arthralgia, and weight changes are the most common symptoms in new cases or recurrent active SLE flares.
What is systemic lupus erythematosus?
Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels.
What is the treatment for systemic lupus erythematosus?
SLE treatment consists primarily of immunosuppressive drugs that inhibit activity of the immune system. Hydroxychloroquine and corticosteroids (e.g., prednisone) are often used to treat SLE. The FDA approved belimumab in 2011, the first new drug for SLE in more than 50 years.
Which antibodies are specific for systemic lupus erythematosus (SLE)?
Anti-Ribosomal-P antibodies are very specific for SLE, although their prevalence in SLE is less than 5%, and they may correlate with neuropsychiatric manifestations of SLE. Anti-Histone antibodies are not specific for drug-induced lupus and can be seen in 50% to 70% of cases of SLE.
What causes systemic lupus erythematosus (SLE) flares?
The use of estrogen-containing contraceptives and postmenopausal hormone replacement therapy can cause flares in patients with SLE and have been associated with a higher incidence of SLE. Elevated levels of prolactin are seen in patients with SLE.