What is vildagliptin tablets used for?
Vildagliptin is a DPP-4 inhibitor approved for the treatment of type 2 diabetes. Glucagon-like peptide-1 (GLP-1) is a hormone that is rapidly released from the intestine after eating. GLP-1 signals to the pancreas to increase insulin release, and reduce glucagon release, after a meal.
Why is vildagliptin combined with metformin?
Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus.
Does vildagliptin have metformin?
Galvumet contains two ingredients: vildagliptin, which belongs to a class of medicines called ‘islet enhancers’, and metformin, which belongs to the ‘biguanide’ class. Type 2 diabetes mellitus used to be known as ‘non-insulin-dependent diabetes mellitus (NIDDM)’ or ‘maturity onset diabetes’.
Is vildagliptin safe for long term?
Vildagliptin has been shown to be reasonably safe in clinical trials; however, long-term safety evaluations and clinical experience with the effects of DPP4 inhibition are needed.
Which is better glimepiride or vildagliptin?
Conclusions: When metformin alone fails to maintain sufficient glycaemic control, the addition of vildagliptin provides comparable efficacy to that of glimepiride after 52 weeks and displays a favourable AE profile, with no weight gain and a significant reduction in hypoglycaemia compared with glimepiride.
Which is better vildagliptin vs glimepiride?
Conclusions: Vildagliptin treatment was associated with less fluctuation of glucose levels than glimepiride treatment as assessed by 24-h CGM device, suggesting vildagliptin may have the potential to offer long-term beneficial effects for patients with T2DM in preventing the development of complications of diabetes.
Can we take glimepiride and vildagliptin together?
Vildagliptin 50 mg twice-daily was well tolerated when added to glimepiride in Japanese patients with T2D who were inadequately controlled with monotherapy, resulting in improved glycemic control after 12 weeks of treatment.
Is vildagliptin safe?
Further evidence comes from a systematic review and meta-analysis, which concluded that vildagliptin is a safe therapeutic option for patients with T2DM, both as monotherapy and as add-on treatment. Vildagliptin is approved for use as monotherapy and in combination with other anti-hyperglycaemic agents.
Can I take glimepiride with vildagliptin?
Which is more effective vildagliptin or glimepiride?
Conclusion. Vildagliptin-metformin treatment provided blood glucose control efficacy comparable to that of glimepiride-metformin treatment and resulted in better adverse event profiles with lower risks of hypoglycemia and weight gain.
Which is best vildagliptin or glimepiride?
Which is better linagliptin vs vildagliptin?
Moreover, as far as we know, this study is the first to compare vildagliptin, sitagliptin, and linagliptin as add-on therapy for T2DM patients with background insulin treatment. And what is more, our results indicate that vildagliptin is more effective in decreasing HbA1c.