Table of Contents
What is the therapeutic effect for aspirin?
Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID).
What are the 4 therapeutic effects of aspirin?
Everyday uses include relieving headache, reducing swelling, and reducing a fever. Taken daily, aspirin can lower the risk of cardiovascular events, such as a heart attack or stroke, in people with a high risk.
Is aspirin a therapeutic drug?
Therapeutic drug levels for aspirin are 150 to 300 mcg/mL (salicylate). Plasma levels of aspirin can range from 3 to 10 mg/dL for therapeutic doses to as high as 70 to 140 mg/dL for acute toxicity.
What molecule does aspirin inhibit?
He proved that aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) inhibit the activity of the enzyme now called cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever.
Is aspirin a COX-1 or COX-2 inhibitor?
Aspirin, indomethacin, and ibuprofen were more potent inhibitors of COX-1 than COX-2 in all models used.
What is the pharmacokinetics of aspirin?
Pharmacology/Pharmacokinetics Aspirin is rapidly absorbed in the upper gastrointestinal (GI) tract and results in a measurable inhibition of platelet function within 60 minutes. This antiplatelet effect is associated with prolongation of the bleeding time and inhibition of TXA2-dependent platelet aggregation.
How does an aspirin molecule work?
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and indomethacin work by inhibiting an enzyme that produces prostaglandins–hormone-like messenger molecules that trigger many processes in the body, including inflammation.
What do COX enzymes do?
The enzymes that produce prostaglandins are called cyclooxygenase (COX). There are two types of COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever; however, only COX-1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining.
What is the molecular structure of aspirin?
C₉H₈O₄Aspirin / Formula
Is aspirin a selective COX-2 inhibitor?
COX inhibitors divide into non-selective nonsteroidal anti-inflammatory drugs (NSAIDs), COX-2 selective nonsteroidal anti-inflammatory drugs (c2s NSAIDs), and aspirin. NSAIDs include ibuprofen, naproxen, ketorolac, and indomethacin.
What is the mechanism of action of aspirin?
Aspirin is a Nonsteroidal Anti-inflammatory Drug and Platelet Aggregation Inhibitor. The mechanism of action of aspirin is as a Cyclooxygenase Inhibitor.
Is aspirin an anti-inflammatory drug?
Aspirin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of aspirin is as a Cyclooxygenase Inhibitor. The physiologic effect of aspirin is by means of Decreased Prostaglandin Production. The chemical classification of aspirin is Nonsteroidal Anti-inflammatory Compounds.
How does aspirin suppress the production of prostaglandins and thromboxanes?
Aspirin’s ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in
What is aspirin (acetylsalicylic acid)?
Aspirin is an orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties.