What are non erodible inserts?
The Non-erodible ocular inserts include Ocusert, and Contact lens. In the bioerosion mechanism, the insert is comprised of a matrix of bioerodible material in which the drug is dispersed. Contact of the insert with the tear fluid results in controlled sustained release of the drug by bioerosion of the matrix.
What is ocular insert?
Ocular inserts are defined as sterile, thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or conjuctival sac, whose size and shape are especially designed for ophthalmic application. They are composed of a polymeric support that may or may not contain a drug.
Which ocular device that has shape of a flag?
NODS is New ophthalmic delivery system. This device is in the shape of flag. Therefore this is the correct answer.
How do you use lacrisert?
Place LACRISERT® by gently brushing it on the inside of the “pocket”. Gently grasp the outer corner of the lower eyelid between your thumb and index finger and pull out to create a “pocket”. Pull the lower lid up and over the LACRISERT®, then release. Allow LACRISERT® to settle comfortably in the “pocket”.
What pH are eye drops?
A significant parameter to take into account is the pH of the formulation; the physiological pH of the tear fluid ranges from 6.5 to 7.6, 7 and the external surface of the eye tolerates preparations with a pH between 3.5 and 10.5.
Which is matrix type ocular system?
Matrix type drug delivery systems: These are the devices that have the therapeutic agent, which is incorporated or impregnated with in the polymer, for controlled release of drug. E.g.; Hydrophilic soft contact lenses, soluble ocular inserts ( 9).
Which drug is used in Ocusert system?
* The Ocusert therapeutic system is a flat, flexible, elliptical device designed to be placed in the inferior cul-de-sac between the sclera and the eyelid and to release Pilocarpine continuously at a steady rate for 7 days.
How do you prescribe LACRISERT?
Lacrisert Dosage and Administration One Lacrisert ophthalmic insert in each eye once daily is usually sufficient to relieve the symptoms associated with moderate to severe dry eye syndromes.
What is the weight of LACRISERT?
LACRISERT® (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye. The molecular weight is typically 1 × 106.
What are the 3 primary skin barriers?
Human skin has three major layers: epidermis, dermis, and hypodermis. Epidermis is the outermost layer of the skin and serves as a waterproof protective barrier against pathogens and debris.
What is the pH of human tears?
6.5 to 7.6
The normal pH range was 6.5 to 7.6; the mean value was 7.0. This method provides a rapid and accurate measure of tear pH and may better our understanding of tear physiology and tear buffering capacity. 1. Carney LG, Hill RM: Human tear pH: Diurnal variations .
Can you get LACRISERT over the counter?
Lacrisert is inserted into the eye to treat dry eye conditions such as burning and itching. Lacrisert works by maintaining moisture in the eye in order to prevent the occurence of dry eye conditions. This brand name medication is available as a prescription and as an over the counter drug.