Table of Contents
How does Phenoxybenzamine treat pheochromocytoma?
Phenoxybenzamine is most commonly used in the treatment of pheochromocytomas. It establishes a “chemical sympathectomy” preoperatively that makes arterial blood pressure less labile during surgical resection of these catecholamine-secreting tumors.
What is Regitine used for?
Regitine is indicated for the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Regitine is also indicated for the diagnosis of pheochromocytoma by the Regitine blocking test.
What is another name for phentolamine?
Phentolamine, sold under the brand name Regitine among others, is a reversible nonselective α-adrenergic antagonist.
How do you use extravasation Regitine?
Phentolamine (Regitine)2,5 Prepare by diluting 5 mg phentolamine in 10 mL of 0.9% sodium chloride. Inject subcutaneously into the extravasation area within 12 hours of extravasation. Blanching should reverse immediately; additional injections may be required if blanching returns.
Why phenoxybenzamine is used in pheochromocytoma?
Factors favoring phenoxybenzamine use are its long duration of action leading to twice daily dosing and that it causes noncompetitive blockade of α-receptors; thus it prevents episodic surges of catecholamine releases during pre- and post-operative period.
Which drug is useful in the treatment of pheochromocytoma?
Noncardioselective beta blockers, such as propranolol (Inderal) or nadolol (Corgard), are the usual choice; however, cardioselective agents, such as atenolol (Tenormin) and metoprolol (Lopressor), also may be used.
What is the antidote for norepinephrine?
Phentolamine is the local antidote for peripheral ischemia resulting from extravasation of norepinephrine. Phentolamine should be given as soon as possible after extravasation is noted.
Is labetalol beta blocker?
Labetalol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.
What drug class is phentolamine?
Phentolamine belongs to a group of medications called vasodilators.
Which antidote is approved for treating parenteral nutrition extravasation?
Hyaluronidase was shown to be successful in the treatment of 2 cases of TPN extravasations with improvement in 6–12 hours.
Is morphine contraindicated in pheochromocytoma?
Drugs like morphine (histamine release) and pethidine (sympathetic stimulation) are not preferred in pheochromocytoma.
What is the antidote for Regitine?
You used the word “extravasation” and are listing Regitine as the only antidote. Extravastion is used when there is leakage of any vesciant medications from the vein.
How do I prepare Regitine (phentolamine)?
Prepare Regitine (Phentolamine). 7. Take (2) 5mg/1ml vials and dilute with 10ml 0.9% normal saline, in 20ml syringe. 8. Inject 6ml through the indwelling IV catheter at the site. (Some resources indicate this may not be indicated) 9. Inject the remaining 6ml in 0.5ml increments SQ around the extravasation site. 10.
What is the USP for Regitine?
Regitine, phentolamine mesylate for injection, USP, is an antihypertensive, available in vials for intravenous and intramuscular administration. Each vial contains phentolamine mesylate USP, 5 mg, and mannitol USP, 25 mg, in sterile, lyophilized form.
What is the generic name for Regitine?
Regitine Description. Regitine, phentolamine mesylate for injection, USP, is an antihypertensive, available in vials for intravenous and intramuscular administration. Each vial contains phentolamine mesylate USP, 5 mg, and mannitol USP, 25 mg, in sterile, lyophilized form.