What is the treatment protocol for use of N-acetylcysteine?
The US FDA approved dosage regimen of oral acetylcysteine involves a load- ing dose of 140 mg/kg followed by 17 doses of 70 mg/kg at 4 hour intervals (total duration of treatment, 72 hours).
What is the route of administration of acetylcysteine as ordered?
The medicine is inhaled through a face mask, mouthpiece, or tracheostomy. The 10 or 20% solution may be used for inhalation as a heavy mist in a tent or croupette. Sometimes the 10 or 20% solution is placed directly into the trachea or through a catheter into the trachea for certain conditions.
What is contraindicated with NAC?
Intravenous acetylcysteine is contraindicated in patients who have had a previous anaphylactoid reaction to acetylcysteine, and acetylcysteine solution for oral use or inhalation is contraindicated in patients who have had any type of hypersensitivity reaction to the drug.
Can you give Mucomyst IV?
The newer 48-hour protocol consists of a loading dose of 140 mg/kg followed by 12 doses of 70 mg/kg every 4 hours. As previously noted, although not approved by the FDA, oral acetylcysteine has effectively been used intravenously in the United States.
Can you give mucomyst IV?
Can you take NAC with high blood pressure?
Blood pressure medications, angiotensin-converting enzyme (ACE) inhibitors — NAC may enhance the blood pressure-lowering effects of ACE inhibitors, medications commonly used to treat high blood pressure.
Can I take NAC with metoprolol?
No interactions were found between Alz-Nac and Metoprolol Succinate ER.
How do you administer Mucomyst?
When nebulized into a face mask, mouth piece, or tracheostomy, 1 to 10 mL of the 20% solution or 2 to 20 mL of the 10% solution may be given every 2 to 6 hours; the recommended dose for most patients is 3 to 5 mL of the 20% solution or 6 to 10 mL of the 10% solution 3 to 4 times a day.
What blood pressure medications interact with NAC?
Nitroglycerin and isosorbide — Although NAC may enhance the effectiveness of nitroglycerin and isosorbide (Isordil), two medications commonly used to treat chest pain. This combination may also increase the risk of side effects such as severe headaches and may lead to abnormally low blood pressure.
What blood pressure meds does NAC interact with?
Does NAC affect blood pressure?
In in vivo animal studies of hypertension, NAC not only reduced blood pressure but also was effective at reducing oxidative stress and improving antioxidant capacity.
Can NAC cause tachycardia?
NAC is known to cause adverse effects in up to 10% of patients, including anaphylactoid reactions such as hypotension, tachycardia, bronchospasm and respiratory distress.
When should NAC protocol be stopped?
When an anaphylactoid reaction occurs, NAC should be stopped immediately, and the patient treated with anti-histamine medication (e.g., diphenhydramine) and IV fluid for hypotension. Vasopressors are not typically necessary.