Table of Contents
What happens if neural crest cells fail to migrate?
Failure of neural crest cell migration from these regions to the colon results in the absence of enteric ganglia and thus to the absence of peristaltic movement in the bowels. The cardiac neural crest is located between the cranial and trunk neural crests.
What happens to the neural crest during development?
Early in the process of development, vertebrate embryos develop a fold on the neural plate where the neural and epidermal ectoderms meet, called the neural crest. The neural crest produces neural crest cells (NCCs), which become multiple different cell types and contribute to tissues and organs as an embryo develops.
What is the main role of neural crest cells migration?
Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs.
Do neural crest cells migrate?
In fact, neural crest cells undergo the most extensive migration of any embryonic cell type in vertebrate embryos.
What is the fate of neural crest cells?
Cells of the neural crest migrate to different locations in the body to form the paravertebral and prevertebral ganglionic chain as well as chromaffin tissues that later form the adrenal medulla.
What is the significance of the neural crests cells in the formation of the tooth germ?
The cranial neural crest cells are crucial to craniofacial tissue and organ development including tooth organ. They give rise to various dental tissues including pulp, dentin, cement, and periodontal tissue (Chai et al., 2000).
What is the neural crest and what is its importance?
The neural crest is a transient embryonic structure in vertebrates that gives rise to most of the peripheral nervous system (PNS) and to several non-neural cell types, including smooth muscle cells of the cardiovascular system, pigment cells in the skin, and craniofacial bones, cartilage, and connective tissue.
What is critical to the development of neural crest cell derivatives?
Twist, a bHLH transcription factor, is required for mesenchyme differentiation of the pharyngeal arch structures. Id is a direct target of c-Myc and is known to be important for the maintenance of neural crest stem cells.