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What are the indications for Neupogen?
NEUPOGEN® is indicated for chronic administration to reduce the incidence and duration of sequelae of severe neutropenia (e.g.‚ fever‚ infections‚ oropharyngeal ulcers) in symptomatic patients with congenital neutropenia‚ cyclic neutropenia‚ or idiopathic neutropenia.
Does Neupogen help white blood cells?
Neupogen® (filgrastim) is a drug that has been used successfully for cancer patients to stimulate the growth of the white blood cells, making patients less vulnerable to infections, it is expected to help patients who have bone marrow damage from very high doses of radiation in much the same way.
When do you administer Neupogen?
Administer NEUPOGEN at least 24 hours after cytotoxic chemotherapy. Do not administer NEUPOGEN within the 24-hour period prior to chemotherapy [see Warnings and Precautions (5.11)]. A transient increase in neutrophil count is typically seen 1 to 2 days after initiation of NEUPOGEN therapy.
Does Neupogen increase lymphocytes?
In all studies to date‚ absolute counts of both eosinophils and basophils did not change and were within the normal range following administration of NEUPOGEN®. Increases in lymphocyte counts following NEUPOGEN® administration have been reported in some normal subjects and cancer patients.
What injection is given for low WBC?
Filgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Filgrastim helps the bone marrow to make new white blood cells.
Can Neupogen cause leukocytosis?
Growth factor induced leukocytosis is directly proportional to age (Table 1). Females are more susceptible to leukocytic response than males (Table 2). Leukostasis is rare with growth factors, Neulasta > Neupogen (Table 3, 4)….
| Leukocytosis in | Female | Male |
|---|---|---|
| Neupogen | 52.83% | 47.17% |
| Neulasta | 66.53% | 33.47% |
How long can you take Neupogen?
Patients receiving chemotherapy or who have received a bone marrow or stem cell transplant are only required to use NEUPOGEN for short periods of time until the number of infection-fighting neutrophils are restored (usually 1 to 3 weeks). Stem cell donors should receive NEUPOGEN treatment for 4 to 5 days.
How long is Neupogen effective?
Your doctor will tell you when to begin your treatment and when to stop. are only required to use NEUPOGEN for short periods of time until the number of infection-fighting neutrophils are restored (usually up to 14 days, but can be longer). Stem cell donors would normally receive NEUPOGEN treatment for 4 to 7 days.
What would indicate a need for filgrastim?
Filgrastim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy, chronic neutropenia, or exposure to large amounts of radiation).
What drugs increase WBC count?
Drugs that may increase WBC counts include epinephrine, allopurinol, aspirin, chloroform, heparin, quinine, corticosteroids, and triamterene.
Does filgrastim increase WBC?
Does Neupogen increase platelets?
There were no effects on red blood cell or platelet levels. In a randomized‚ placebo-controlled trial‚ 70 patients with myeloid and nonmyeloid malignancies were treated with myeloablative therapy and allogeneic bone marrow transplant followed by 300 mcg/m2/day of a Filgrastim product.
How long does Neupogen take to work?
What injection is given for low white blood cell count?
What is leukopenia and what does it mean?
Leukopenia is a low white blood cell (leukocyte) count that indicates a decrease in disease-fighting cells in your body. Leukopenia can indicate a variety of health complications, including serious infections, diseases, and cancer. Leukopenia can involve one or more types of white blood cells and may include neutropenia, monocytopenia, and more.
Can a person with leukopenia have neutropenia?
A person who develops an infection of the spleen can also experience chronic leukopenia. Leukopenia refers to a reduced number of total white blood cells. A person with leukopenia can have a reduction in any type of white blood cell. Neutropenia is a type of leukopenia.
How to use Neupogen to treat low neutrophil count during chemotherapy?
Using Neupogen to Treat Low Neutrophil Count During Chemotherapy 1 Overview. Neupogen (filgrastim) is a drug given to people receiving chemotherapy who have… 2 Administration. You will have injections of Neupogen once daily until your white blood cell counts… 3 Side Effects. Not everyone will have side effects on Neupogen,…
How can leukopenia be prevented?
You can’t prevent leukopenia, but can you can take actions to prevent infections when your white blood cell count is low. That’s why your treatment will include eating well, resting, and avoiding injuries and germs. If you have trouble doing any of these, talk with your doctor, nurse, or a dietitian.