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What is atovaquone proguanil good for?
The combination of atovaquone and proguanil is used to treat a certain kind of malaria infection (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent a certain kind of malaria infection in travelers who visit areas where malaria is common.
What is another name for atovaquone proguanil?
Malarone is a combination of two drugs, atovaquone plus proguanil, in one tablet. It is available in the United States as the brand name, Malarone.
Who makes atovaquone?
Currently, atovaquone is marketed as Mepron (GlaxoSmithKline), a yellow crystalline solid in a citrus-flavored liquid suspension (750 mg of atovaquone/5 ml of suspension) (product information, Mepron [atovaquone] suspension, 1999, GlaxoWellcome).
Who invented Malarone?
History. Glaxo Wellcome patented the combination of atovaquone and proguanil to treat malaria in 1999.
Who manufactures atovaquone?
Glenmark Pharmaceuticals has received its first Food and Drug Administration approval for its generic Malarone (atovaquone and proguanil hydrochloride tablets). It marks the first approval for a product that will be manufactured at the company’s new manufacturing facility in Monroe, N.C., Glenmark said.
Can Malarone cause depression?
Common side effects of Malarone are dizziness, depression and sleeping problems. People who take Malarone to experience unusual dreams, fever, an itchy rash, a cough, or to find that their appetite decreases.
What is atovaquone/proguanil?
Atovaquone/proguanil, sold under the brand name Malarone among others, is a fixed-dose combination medication used to treat and prevent malaria, including chloroquine -resistant malaria. It contains atovaquone and proguanil.
When to stop prophylaxis of atovaquone + proguanil?
(6) According to the French licensing terms, atovaquone + proguanil prophylaxis can be stopped 7 days after leaving an endemic area, rather than 3-4 weeks with other drugs. This recommendation is based on weak evidence: mainly on theoretical arguments and on the absence of clinical malaria in some patients with evidence of P. falciparum infection.
How much proguanil is in Malarone tablets?
A standard tablet of Malarone contains 100 mg of proguanil hydrochloride and 250 mg of atovaquone. A pediatric tablet contains 25 mg of proguanil hydrochloride and 62.5 mg of atovaquone. Glaxo Wellcome patented the combination of atovaquone and proguanil to treat malaria in 1999.
Is there a generic version of atovaquone?
Glaxo Wellcome patented the combination of atovaquone and proguanil to treat malaria in 1999. Patent protection expired in 2013. The U.S. Food and Drug Administration (FDA) approved a generic formulation from Glenmark Generics in 2011.