What is cytochrome P450 2c9 CYP2C9 substrates?
Substrates for CYP2C9 include fluoxetine, losartan, phenytoin, tolbutamide, torsemide, S-warfarin, and numerous NSAIDs. CYP2C9 activity in vivo is inducible by rifampicin.
How does CYP2C9 affect metabolism?
In humans, the protein is encoded by the CYP2C9 gene. The gene is highly polymorphic, which affects the efficiency of the metabolism by the enzyme….CYP2C9.
| RNA expression pattern | |
|---|---|
| BioGPS | More reference expression data |
What is CYP2C9 inhibitor?
CYP2C9 is inhibited by amiodarone, fluconazole, and sulphaphenazole among other drugs [9]. Dangerous drug- drug interaction can arise when an inhibitor such as one of these is added to a therapeutic regime that includes drugs with a low therapeutic index, such as S-warfarin, tolbutamine, and phenytoin [40-42].
What does the CYP2C9 gene do?
The CYP2C9 gene provides instructions for making an enzyme that is found in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The CYP2C9 enzyme breaks down (metabolizes) compounds including steroid hormones and fatty acids.
What induces CYP2C9?
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther.
What is the CYP2C19 gene?
The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.
How do you test for CYP2C9?
Methodology: DNA analysis is performed by allele-specific real-time polymerase chain reaction (PCR) to detect the *2 and *3 alleles in the CYP2C9 gene. No other variants in this gene are detected by this assay. Molecular-based testing is highly accurate, but as in any laboratory test, rare diagnostic errors may occur.
What is CYP2C19 genotype?
What is CYP2C9 * 3?
CYP2C9 is the primary enzyme responsible for inactivating warfarin. The CYP2C9*3 variant allele has been shown to cause an 80% decrease in enzymatic activity of CYP2C9 and therefore contributes to the dose variance of warfarin [4].
What is CYP2C19 metabolizer?
CYP2C19 is an enzyme that is responsible for breaking down (metabolizing) several of the drugs that are commonly used today. Some medications, such as clopidogrel, require activation by CYP2C19 in order for the medication to be effective.
What is CYP2C19 genotyping?
What are the CYP2C9 variant alleles recommended by PGx?
CYP2C9 variant alleles recommended as Tier 1 by the PGx Working Group include CYP2C9 *2, *3, *5, *6, *8, and *11. This recommendation was based on their well-established functional effects on CYP2C9 activity and drug response availability of reference materials, and their appreciable allele frequencies in major ethnic groups.
Why is the CYP2C9 gene highly polymorphic?
The gene is highly polymorphic, which affects the efficiency of the metabolism by the enzyme. CYP2C9 is a crucial cytochrome P450 enzyme, which plays a significant role in the metabolism, by oxidation, of both xenobiotic and endogenous compounds.
What is CYP2C9 used for?
Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein. The enzyme is involved in metabolism, by oxidation, of both xenobiotics, including drugs, and endogenous compounds, including fatty acids.
Why do we need mouse genotyping?
As overall experimental costs increase each year along with mouse colony maintenance costs, the need for quick and accurate mouse genotyping is essential for reducing undesired strain genotypes and for responsible mouse husbandry.