What does DIPEA stand for?
di-isopropyl-ethyl amine. di-isopropyl-ethyl-amine. ethyl (diisopropyl)amine.
What is the PKA of DIPEA?
7087-68-5
| Melting point | <-50 °C (lit.) |
|---|---|
| pka | 10.98±0.28(Predicted) |
| form | Liquid |
| Specific Gravity | 0.755 (20/4℃) |
| color | APHA: <20 |
Is diisopropylamine an organic compound?
Diisopropylamine is a common amine nucleophile in organic synthesis.
Is triethanolamine an oil?
What Is Triethanolamine? Triethanolamine (TEA) is a tertiary amino compound and triol (a compound containing three hydroxyl groups). It is a colorless, oily liquid, denser than water, and smells slightly like ammonia as it has nitrogen in the center.
What is triethanolamine made from?
“Triethanolamine (TEA) is a clear, colorless, thick liquid that smells a bit like ammonia because it has nitrogen at its center,” Romanowski says. As he explains it, triethanolamine is made by reacting ethylene oxide, which is derived from the petroleum industry, with ammonia, which is derived from air.
Is diisopropylamine a base?
General description. N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions.
Is diisopropylamine basic?
General description. Diisopropylamine (DIPA) is an aliphatic secondary amine widely used as an organic base in organic synthesis.
How do you purify diisopropylamine?
Diisopropylamine is purified by heating to reflux over sodium hydroxide (NaOH) for 3–12 hr, followed by simple distillation from NaOH. 4. Butyllithium in hexanes (2.5 M) is purchased from Aldrich Chemical Company, Inc., and titrated using diphenylacetic acid. 5.
Is triethanolamine a pH?
All Answers (2) Triethanolamine (TEA) is a viscous organic compounds having both a tertiary amine and a triol. TEA is a strong base of 1% solution have a pH of approximately 10.
Is diisopropylamine a good Nucleophile?
Diisopropylamide ion (1), usually prepared as the lithium salt (2), is a strong base but, due to steric hindrance at the electron-rich nitrogen atom caused by the bulky isopropyl groups, a very weak nucleophile.
What is the role of DIPEA in amide coupling reactions?
It is commonly used as the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example, as an acid chloride, as illustrated below) and a nucleophilic amine. As DIPEA is hindered and poorly nucleophilic, it does not compete with the nucleophilic amine in the coupling reaction.
What is the name of the compound formed when DIPEA reacts with disulfur dichloride?
DIPEA forms a complex heterocyclic compound called scorpionine (bis ([1,2]dithiolo)- [1,4]thiazine) upon reaction with disulfur dichloride that is catalyzed by DABCO in a one-pot synthesis.
What is the license for the Thieme chemistry contribution?
The Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated. Works produced by the U.S. government are not subject to copyright protection in the United States.
How do you make DIPEA from diethyl sulfate?
DIPEA is commercially available. It is traditionally prepared by the alkylation of diisopropylamine with diethyl sulfate. Pure DIPEA exists as a colorless liquid, although commercial samples can be slightly yellow. If necessary, the compound can be purified by distillation from potassium hydroxide or calcium hydride.