What is used to treat heparin induced thrombocytopenia?
A direct thrombin inhibitor, such as lepirudin, danaparoid or argatroban, is considered the agent of choice for treatment of HIT.
What is cryoprecipitate used for?
Cryo is used to prevent or control bleeding in people whose own blood does not clot properly. This includes patients with serious but rare hereditary conditions such as Hemophilia A (who lack factor VIII) and von Willebrand disease (who lack von Willebrand factor).
How is HIT heparin treated?
Treatment of HIT entails immediate withdrawal of all heparin, including heparin-containing flushes and catheters. Heparin cessation alone, however, is often insufficient to prevent thrombosis.
When can I start argatroban after heparin?
Initiate argatroban within 2 hours after discontinuation of heparin infusion.
Is TXA contraindicated in DIC?
Solo use of tranexamic acid is contraindicated for DIC associated with aortic dissection.
Do you treat DIC with heparin?
Heparin, as an anticoagulant, which, not only inhibits the activation of the coagulation system, but is also an anti-inflammatory and immunomodulatory agent, has been widely used during DIC treatment and in the prevention and treatment of thrombotic diseases.
How many units of FFP reverse INR?
Give FFP 2 units IV by rapid infusion. Check INR 15 minutes after completion of infusion. If INR ≥1.5, administer 2 additional units of FFP IV rapid infusion.
How much FFP do you give for elevated INR?
FFP = fresh frozen plasma; INR = international normalized ratio. Because the original study1 had limited data on subjects with INRs greater than 11, exact numbers are not provided for such INR levels. a FFP = fresh frozen plasma; INR = international normalized ratio….Formula for Fresh Frozen Plasma Dosing for Warfarin Reversal.
| Initial INR | FFP (U) |
|---|---|
| 1.5-1.9 | 1 |
| 2-3 | 2 |
| 3-4 | 3 |
| 4-8 | 4 |