Table of Contents

## How do you convert to morphine equivalents?

Use the formula: Strength per Unit X (Number of Units/ Days Supply) X MME conversion factor = MME/Day.

## What is Endone equivalent to?

Endone 5mg x 6 = 30mg of oral Oxycodone in 24hrs. Total oral Oxycodone requirement in 24hrs is 60+30mg = 90mg. Using Table A of guideline to convert to oral Morphine equivalent factor is 1.5. Therefore 90 x 1.5 = 135mg of oral Morphine equivalent.

**How do you do opioid conversions?**

Determine equivalent daily dose of new opioid by dividing the calculated MMEs of current opioid by new opioid’s conversion factor. Reduce this amount by 25-50% and then divide into appropriate intervals.

**How do you convert morphine IV to morphine?**

Example: Change from 90 mg q12 Extended Release Morphine to IV Hydromorphone as a continuous infusion.

- Calculate the 24 hour current dose: 90 Q12 x 2 = 180 mg PO Morphine/24 hrs.
- Use the equianalgesic ratio of PO to IV morphine: 30 mg po Morphine = 10 mg IV Morphine.

### What is the conversion factor of morphine to fentanyl?

Assumption two 3,11: morphine (oral) 2 mg = transdermal fentanyl 1 mcg/hour. ‘Breitbart method’ morphine (oral) 50mg = transdermal fentanyl 25 mcg/hour. (x /30) * 50 = 0.6 or 50x = 18 –> x = 0.36 (conversion factor) Conversion from these dosage forms are 1:1 but require special handling.

### How do I convert 60 mg of morphine to morphine (IV)?

Morphine (oral) 1 30mg 1. To convert 60 mg of Morphine (sc) 2 to 1 15mg oral Morphine to Morphine (iv) 3 to 1 10mg subcutaneous Morphine Diamorphine (sc) 3 to 1 10mg divide by 2 to give 30 mg. Oxycodone (oral) 1.5-2 to 1 15-20mg Oxycodone (sc) 3 to 1 10mg 2.

**How do you calculate breakthrough dose of morphine?**

The breakthrough dose of any opioid except fentanyl should be one sixth of the total daily dose . See note below on renal failure. Morphine (oral) 1 30mg 1. Morphine (sc) 2 to 1 15mg oral Morphine to Morphine (iv) 3 to 1 10mg subcutaneous Morphine Diamorphine (sc) 3 to 1 10mg divide by 2 to give 30 mg.

**How do you convert morphine to oxycodone?**

Morphine (sc) 2 to 1 15mg oral Morphine to Morphine (iv) 3 to 1 10mg subcutaneous Morphine Diamorphine (sc) 3 to 1 10mg divide by 2 to give 30 mg. Oxycodone (oral) 1.5-2 to 1 15-20mg Oxycodone (sc) 3 to 1 10mg 2. NB. At lower doses, fentanyl conversions are less accurate.