Table of Contents
Why is propofol so short acting?
The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.
Why do most drugs follow first order kinetics?
FIRST-ORDER KINETICS For most drugs, we need only consider first-order and zero-order. Most drugs disappear from plasma by processes that are concentration-dependent, which results in first-order kinetics. With first-order elimination, a constant percentage of the drug is lost per unit time.
What is PK concentration?
Pharmacokinetics, or PK, is the monitoring of the concentration level over time of an analyte within a human (or animal) body.
What are the 5 steps of pharmacokinetics?
Pharmacokinetics is the movement of a drug through the body’s biological systems, these processes include absorption, distribution, bioavailability, metabolism, and elimination.
What are the three main phases of drug action?
A tablet or capsule taken by mouth goes through three phases—pharmaceutic, pharmacokinetic, and pharmacodynamic—as drug actions occur. In the pharmaceutic phase, the drug becomes a solution so that it can cross the biologic membrane.
What is Tmax Cmax and AUC?
Abstract. The three classical pharmacokinetic parameters used to assess bioequivalence, AUC (total area from zero to infinity), Cmax (peak plasma concentration), and tmax (time to reach Cmax), are suitable to determine the extent and rate of absorption of immediate-release drug products.
What is anesthesiology conferences 2022?
Anesthesiology Conferences 2022/2023/2024 is an indexed listing of upcoming meetings, seminars, congresses, workshops, programs, continuing CME courses, trainings, summits, and weekly, annual or monthly symposiums.
What is the relationship between first-order kinetics and elimination?
First-order kinetics proportionally increases elimination as the plasma concentration increases, following an exponential elimination phase as the system never achieves saturation.
Why are first order reactions said to follow linear kinetics?
It is because of such proportionality between rate of reaction and the concentration of drug that a first-order process is said to follow linear kinetics (Fig. 8.3.). Fig. 8.3. Graph of first-order kinetics showing linear relationship between rate of reaction and concentration of drug (equation 8.10). Rearrangement of equation 8.10 yields:
What is the difference between first order and zero order kinetics?
Function The fundamental difference between zero and first-order kinetics is their elimination rate compared to total plasma concentration. Zero-order kinetics undergo constant elimination regardless of the plasma concentration, following a linear elimination phase as the system becomes saturated.