Table of Contents
What is seminoma vs non seminoma?
Seminomas are very sensitive to radiation therapy. Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to these different cell types: Choriocarcinoma (rare)
What is mediastinal seminoma?
Mediastinal seminoma is a malignant germ cell tumor in the mediastinum. The tumor usually occurs in the anterior-superior mediastinum in males aged 20-40 years old. The first-line treatment is with cisplatin based chemotherapy.
What does Nonseminomatous mean?
Listen to pronunciation. (NON-seh-mih-NOH-muh) A type of cancer that begins in cells that form sperm or eggs. There are several types of nonseminoma tumors, including embryonal carcinoma, malignant teratoma, choriocarcinoma, and yolk sac tumor.
Why is LDH elevated in dysgerminoma?
Since LDH is a glycolytic enzyme it may be abundant in dysgerminoma cells. Changes in the permeability of the tumor cell membranes or necrosis of tumor cells may release enzymes into the circulation, but in such cases one should expect other enzymes to be as markedly elevated as LDH.
What does Seminomatous mean?
Listen to pronunciation. (SEH-mih-NOH-muh) A type of cancer that begins in germ cells in males. Germ cells are cells that form sperm in males or eggs in females.
How is Dysgerminoma diagnosed?
The diagnosis of dysgerminomas requires either laparoscopy or laparotomy….The standard workup for suspected dysgerminomas includes the following tumor markers:
- Lactate dehydrogenase (LDH)
- Beta-human chorionic gonadotropin (beta-hCG)
- Alpha-fetoprotein (AFP)
- Inhibin A and B.
- Cancer antigen 125 – For epithelial tumors.
What can cause high LDH levels?
Disorders that cause high LDH levels include:
- Anemia.
- Kidney disease.
- Liver disease.
- Muscle injury.
- Heart attack.
- Pancreatitis.
- Infections, including meningitis, encephalitis, and infectious mononucleosis (mono)
- Certain types of cancer, including lymphoma and leukemia.
What is the meaning of dysgerminoma?
(DIS-jer-mih-NOH-muh) A type of cancer that begins in germ cells in females. Germ cells are cells that form sperm in males or eggs in females. Dysgerminomas occur most often in the ovaries, but they may also occur in other areas of the body, including the central nervous system.