Table of Contents
What does a high beta-2 microglobulin?
High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.
What is a beta 2 globulin?
Beta-2 microglobulin (B2M) is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by B lymphocytes and tumor cells.
What is a normal beta-2 microglobulin?
The laboratory range for normal serum beta 2 microglobulin values was 1.1 to 2.4 mg/L. Patients without documented testicular tumors had values ranging from 1.4 to 9.7 mg/L. Values for normal controls ranged from 1.7 to 2.4 mg/L.
What is a beta-2 microglobulin test?
Description. The beta-2 microglobulin (B2M) blood test is used to help detect kidney damage and follow kidney disorders, to help evaluate the severity and prognosis of certain cancers such as multiple myeloma and some lymphomas, and it is sometimes used to monitor people who are exposed to cadmium.
What causes high beta 2 globulin?
Beta 2 microglobulin is frequently elevated in the blood with cancers such as multiple myeloma and lymphoma and with inflammatory disorders and infections (e.g., HIV, CMV). Because beta 2 microglobulin is increased with blood cell cancers, it may be useful as a tumor marker.
What does low beta 2 globulin mean?
Low serum levels of beta2 microglobulin essentially indicate decreased disease activity in conditions for which beta2 microglobulin is used as a prognostic marker (multiple myeloma, lymphoma, leukemia) or the absence of such a disease process.
What does a high beta 2 glycoprotein mean?
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
What is a high beta 2 level?
Purpose: Elevated serum beta-2 microglobulin (beta 2M) levels are associated with poor prognosis in several lymphoproliferative disorders including multiple myeloma and lymphoma. Their prognostic relevance in acute lymphocytic leukemia (ALL) is unknown.
What causes positive beta 2 glycoprotein?
What is beta 2 microglobulin?
Beta-2 microglobulin. β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excludes red blood cells ). In humans, the β 2 microglobulin protein is encoded by the B2M gene.
What is beta2-microglobulin and why is it important in multiple myeloma?
Multiple myeloma is a cancer of a certain kind of white blood cell, called a plasma cell. At the time of diagnosis, the Beta2-microglobulin levels reflect how advanced the disease is and the likely prognosis for that person. Because Beta-2 Microglobulin is increased with blood cell cancers, it may be useful as a tumor marker.
What does β2 mean?
Levels of β2 microglobulin can be elevated in multiple myeloma and lymphoma, though in these cases primary amyloidosis (amyloid light chain) and secondary amyloidosis (amyloid associated protein) are more common. The normal value of β2 microglobulin is <2 mg/L.
What is beta 2 microglobulin dialysis-associated amyloidosis?
In people with kidney disease who are undergoing dialysis, beta 2 microglobulin can form long protein chains that can be deposited in joints and tissues, causing stiffness and pain. This condition is called beta 2 microglobulin dialysis-associated amyloidosis.