What is an extemporaneous suspension?
Extemporaneous preparation is one facet of unlicensed drug use and includes modifications to commercially manufactured products such as the preparation of suspension or powders from tablets or the preparation of a product from the individual raw materials.
How are suspensions administered?
Suspension dosage forms are given by the oral route, injected intramuscularly or subcutaneously, instilled intranasally, inhaled into the lungs, applied to the skin as topical preparations, or used for ophthalmic or otic purposes in the eye or ear, respectively.
Is suspension an injectable preparation?
Injectable suspensions are heterogonous system, containing solid dispersed phase. They are limited to either subcutaneous or intramuscular routes of administration. Intravenous administration may result in vasoocclusion.
What are extemporaneous drugs?
An extemporaneous preparation (compound) is a drug or mixture of drugs prepared or compounded in a pharmacy according to the order of a prescriber.
How do you prepare omeprazole suspension?
Method of Preparation: Calculate the needed quantity of each ingredient. Accurately weigh or measure each ingredient. Place the sodium bicarbonate in a suitable container, add about 50 mL of purified water, and mix well. Add the omeprazole, followed by sufficient additional purified water, to final volume and mix well.
What is the difference between a suspension and a colloid?
Particles in a suspension are usually more than 1,000 nm, while those in a colloid range from 1-1,000 nm. Unlike those in a suspension, particles in a colloid do not separate when sitting still. The particles in a suspension may be separated by filtration unlike those in a colloid.
What are the 2 types of suspension in pharmacy?
Based on the type of the dispersion medium, suspensions can be aqueous or nonaqueous. Identifying the physical state of the dispersion medium allows the suspensions to be classified as solid-in-liquid or solid-in-gas (aerosols) suspensions.
What is suspension formulation?
The suspension is a biphasic liquid or semi-solid dosage form where the finely divided insoluble solid drug particles are homogeneously dispersed in a liquid or semi-solid medium. The solid drug particles act here as the dispersed phase and the liquid or the semi-solid as the dispersion medium.
What are examples of suspension drugs?
Examples of a few of the oral suspensions in which a specific and well defined particle size specification for the drug substance is important include phenytoin suspension, carbamazepine suspension, trimethoprim and sulfamethoxazole suspension, and hydrocortisone suspension.
Why is extemporaneous prepared?
An extemporaneous preparation is a drug specially prepared by a pharmacist because an appropriate drug is not readily available. If no methadone is available, pharmacists can make an extemporaneous preparation using a specified formula.
What is extemporaneous use?
extemporaneous \ek-stem-puh-RAY-nee-us\ adjective. 1 : composed, performed, or uttered on the spur of the moment : impromptu. 2 : provided, made, or put to use as an expedient : makeshift.
What is omeprazole suspension?
Uses of Omeprazole Oral Suspension: It is used to treat gastroesophageal reflux disease (GERD; acid reflux). It is used to treat heartburn. It is used to treat syndromes caused by lots of stomach acid. It is used to treat or prevent ulcers of the swallowing tube (esophagus). It may be given to you for other reasons.
Is omeprazole water soluble?
Omeprazole (Prilosec, C17H19N3O3S, MW 345.42) occurs as a white to off-white powder that melts with decomposition at about 155°C. It is soluble in water 1 g in 8,000 mL. Omeprazole’s degradation rate increases with decreasing acidic pH values, but the drug has acceptable stability under alkaline conditions.
What is an example of colloidal suspension?
Common examples of colloidal suspensions include muddy water, blood, paint, and hot chocolate. These are examples of solid particles in a liquid. Aerosol sprays are another example of colloidal suspensions which are liquid particles in a gas.
What is meant by colloidal suspension?
colloidal suspension in British English (kɒˈlɔɪdəl səˈspɛnʃən ) noun. a mixture having particles of one component, with diameters between 10 −7 and 10 −9 metres, suspended in a continuous phase of another component. The mixture has properties between those of a solution and a fine suspension.
What is extemporaneous product?
Extemporaneous compounding is the preparation of a therapeutic product for an individual patient in response to an identified need. 1. It is a practical way to have medicines supplied when there is no other option.
What is the meaning extemporaneously?
1a(1) : composed, performed, or uttered on the spur of the moment : impromptu an extemporaneous comment. (2) : carefully prepared but delivered without notes or text.
Can omeprazole be extemporaneously compounded?
05/17/2018 (V.01) Bracketed Stability of Extemporaneously Compounded Omeprazole 2, 5 and 10 mg/mL in Oral Mix Dry Alka, SF (Cherry Flavored) Introduction Omeprazole is a drug that acts as a proton pump inhibitor (PPI) to suppress gastric acid secretion.
How do you make omeprazole suspension?
Omeprazole suspension was prepared by emptying the contents of 60 capsules of omeprazole 20 mg into a 1000 mL Erlenmeyer flask. Using a volumetric flask, 600 mL of 8. 4% sodium bicarbonate solution was added to achieve a final omeprazole concentration of 2 mg/mL. The mixture was magnetically stirred for 30 minutes.
Can opioidomeprazole 2 mg/mL be compounded extemporaneously?
Omeprazole 2 mg/mL was compounded extemporaneously in a suspension which was stable for 28 days at 5 ºC. While extemporaneous compounding is a known practice for pharmacist profession, our experience could guide uneducated pharmacists to start compounding of unavailable dosage forms.
How to prepare oral liquid doses of omeprazole 2 mg/mL?
Methods: We established a compounding service for preparation of oral liquid dosage forms at our center which is a tertiary care hospital. Omeprazole 2 mg/mL were prepared using sodium bicarbonate base, placed in 120 mL glass bottles and stored at 5°C for 28 days.