Table of Contents
What does letermovir do?
Letermovir is used to help prevent cytomegalovirus (CMV) infection and disease in certain people who have received a hematopoietic stem-cell transplant (HSCT; a procedure that replaces diseased bone marrow with healthy bone marrow) and are at increased risk of developing a CMV infection.
What is another name for letermovir?
Letermovir (INN; trade name Prevymis) is an antiviral drug for the treatment of cytomegalovirus (CMV) infections.
Who makes Letermovir?
Merck Receives FDA Approval of PREVYMIS™ (letermovir) for Prevention of Cytomegalovirus (CMV) Infection and Disease in Adult Allogeneic Stem Cell Transplant Patients.
Does Letermovir cover HSV?
If letermovir prophylaxis is chosen as the method for prevention, we emphasize the need to provide antiviral drugs for HSV prophylaxis (as letermovir has no activity against HSV, varicella zoster and other herpesviruses).
What is foscarnet used to treat?
Foscarnet is principally used for the treatment of ganciclovir-resistant cytomegalovirus (CMV) infections in patients with the acquired immunodeficiency syndrome (AIDS) or in transplant recipients.
How long do you take Prevymis?
Prevymis tablets or injections are usually given once per day for up to 100 days after your stem cell transplant. Use this medicine for the full prescribed length of time, even if you have no symptoms. Skipping doses may increase your risk of further infection that is resistant to medication.
What is Cytomegalovirus CMV infection?
Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. This virus. It requires a living cell in which to multiply.
What are side effects of foscarnet?
Foscarnet may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- itching, redness, pain, or swelling in the place where you received your injection.
- nausea.
- stomach pain.
- back pain.
- loss of appetite or weight.
- constipation.
- headache.
- vision changes.
Is foscarnet an antibiotic?
Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body. Foscarnet is used to treat cytomegalovirus (CMV) retinitis in people with AIDS. Foscarnet is also used to treat herpes simplex virus (HSV) in people with a weak immune system.
What does Prevymis treat?
PREVYMIS is a prescription medicine to help to prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant. It is not known if PREVYMIS is safe and effective in children under 18 years of age.
Is Prevymis an antibiotic?
Prevymis is an antiviral medicine used to help prevent cytomegalovirus (CMV) infection after a stem cell (bone marrow) transplant from a donor. Prevymis is for use in adults who are seropositive for CMV. Seropositive means that the virus is in your blood even if you do not show any symptoms of infection.
Is CMV harmful?
Occasionally, CMV can cause mononucleosis or hepatitis (liver problem). People with weakened immune systems who get CMV can have more serious symptoms affecting the eyes, lungs, liver, esophagus, stomach, and intestines. Babies born with CMV can have brain, liver, spleen, lung, and growth problems.
How is CMV transplant treated?
How is CMV in transplant patients treated? If you have an active CMV infection that’s causing symptoms, you will need treatment. Antiviral medicines like ganciclovir or valganciclovir can help. These medicines can help control the virus.
Does foscarnet make sleepy?
you should know that foscarnet may make you drowsy or dizzy.
How is Letermovir excreted from the body?
Letermovir undergoes hepatic metabolism and is excreted primarily viathe liver by bile (this is further described, along with its other pharmacokinetic properties, below); therefore, impaired hepatic function may affect letermovir concentration and exposure.
What is the brand name for Letermovir?
Letermovir has recieved both priority and orphan drug status from the FDA. It is currently marketed under the brand name Prevymis 6. For use in prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT) Label.
Is Letermovir effective against human CMV?
Letermovir has a very limited spectrum of antiviral activity. Active in vitro and in vivo against human CMV (HCMV), a human herpesvirus. More potent than ganciclovir against susceptible CMV in vitro and has been active in vitro against some ganciclovir-resistant strains.
How does CMV DNA terminase complex affect Letermovir?
CMV DNA terminase complex is a heterodimeric enzyme with several protein subunits (pUL51, pUL56, pUL89) and is required for viral DNA processing and packaging. By inhibiting the terminase complex, letermovir interferes with production of proper-length genomes and virion maturation. Letermovir has a very limited spectrum of antiviral activity.