Table of Contents
What is cancer cell line encyclopedia?
The Cancer Cell Line Encyclopedia is a database of gene expression, genotype, and drug sensitivity data for human cancer cell lines. Citation(s) Barretina, J et al. (2012) The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature.
Which cell lines are derived from cancer cells?
Human cancer-derived cell lines are fundamental models used in laboratories to study the biology of cancer, and to test the therapeutic efficacy of anticancer agents (1). HeLa was the first cultured cancer line. It was derived from cervical cancer cells taken from Henrietta Lacks in 1951 (2).
What is the nature of cancer?
Cancer is a genetic disease—that is, it is caused by changes to genes that control the way our cells function, especially how they grow and divide. Genetic changes that cause cancer can happen because: of errors that occur as cells divide.
How do you use CCLE?
Getting Started
- Logging in. Your course website is located at http://ccle.ucla.edu.
- Find your course website. After logging in, you will need to find your course website.
- Start editing your course website.
- Change the layout of your course.
- Upload a file.
- Add a link.
- Add text and images onto a section page.
Why are cell lines derived from cancer?
Cell lines derived from cancer cells are frequently used in research, including use as a model to understand cancer and to identify potential new treatments. These cell lines, such as the HeLa cells, are “immortalized” and so continuously grow.
Is cancer part of nature?
Unfortunately, cancer is a natural part of life. Every multicellular creature on earth can get cancer, even in the remotest locations (yes, even sharks get cancer). While some man-made chemicals can indeed cause cancer, they are not the only causes.
What is CCLE?
CCLE (Common Collaboration and Learning Environment) is a campus-wide service that makes collaboration possible across schools, divisions, and departments across UCLA. CCLE is based upon Moodle, an open-source learning management system (LMS), and is administered upon multiple servers.
Does CCLE use Turnitin?
Editing a Turnitin Assignment on CCLE. Click on the Turnitin Assignment you wish to update. There are two ways to edit. Click on the gear icon in the top right of the page and then Edit settings from the drop-down menu to change basic and advanced settings.
How are cell lines made?
The simplest way to create a new cell line is to modify an existing one, a common strategy when an established line already comes close to meeting the requirements. Cells optimized to grow particular viruses or maximize recombinant protein production often come from such modifications.
How do cell lines grow?
Most cell lines can be grown using DMEM culture media or RPMI culture media with 10% Foetal Bovine Serum (FBS), 2 mM glutamine and antibiotics can be added if required (see table below). Check which culture media and culture supplements the cell line you are using requires before starting cultures.
How do I access the cancer cell line Encyclopedia (CCLE)?
Access the CCLE public project by selecting **Cancer Cell Line Encyclopedia (CCLE)** from **Public projects** in the top navigation bar. 2. Place your mouse cursor over the project title.
What can the cancer cell line Encyclopedia do for You?
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Nature. 2012 Mar 28;483(7391):603-7.doi: 10.1038/nature11003.
What is the cancer cell line Encyclopedia (CCLE)?
The Cancer Cell Line Encyclopedia (CCLE) database was conceived to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models (approximately 110 models). Gene expression, mutation, methylation, RNAseq and metabolomics data are downloadable. [14]
Can the cancer cell line Encyclopedia enable predictive modelling of anticancer drug sensitivity?
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Nature. 2012 Mar 28;483(7391):603-7.doi: 10.1038/nature11003. Authors