Table of Contents
What protein is CUG?
CUGBP1
| CELF1 | |
|---|---|
| Aliases | CELF1, BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50, CUGBP, Elav-like family member 1, CUGBP Elav-like family member 1 |
| External IDs | OMIM: 601074 HomoloGene: 136342 GeneCards: CELF1 |
| Gene location (Human) Chr. Chromosome 11 (human) Band 11p11.2 Start 47,465,933 bp End 47,565,569 bp |
What is the role of the poly A binding protein?
The poly(A) binding protein (PABP), which binds the poly(A) tail, interacts with eIF4G and eIF4B to promote circularization of an mRNA and stimulates translation by promoting 40 S subunit recruitment. Thus, these factors serve essential functions in the early steps of protein synthesis.
What is CUG repeats?
The CUG repeats form an extended stem-loop structure with U-U mismatches and G-C Watson-Crick base pairs (9, 10). The clinical features of DM appear to be caused by a “toxic RNA gain-of-function” mechanism in which the CUG repeat tracts bind and sequester specific RNA and DNA binding proteins.
What does the poly A tail do?
The poly-A tail makes the RNA molecule more stable and prevents its degradation. Additionally, the poly-A tail allows the mature messenger RNA molecule to be exported from the nucleus and translated into a protein by ribosomes in the cytoplasm.
What is the 3 poly-A tail and what is its purpose?
What function do the 5 cap and poly-A tail serve on eukaryotic mRNA?
Eukaryotic pre-mRNAs are modified with a 5′ methylguanosine cap and a poly-A tail. These structures protect the mature mRNA from degradation and help export it from the nucleus. Pre-mRNAs also undergo splicing, in which introns are removed and exons are reconnected with single-nucleotide accuracy.
Which of the following do snRNPs bind to?
The snRNPs bind to the pre-mRNA in a specific order to align the splice sites for cleavage, which involves RNA-RNA pairing between the snRNA and the pre-mRNA with the help of the Sm proteins.
What is the function of 5 cap and 3 poly-A tail?
The 5′ cap protests the newly-synthesized mRNA from degradation. It also assists in ribosome binding to help initiating translation. 3′ poly-A tail protects mRNA from degradation, aids in exporting the mature mRNA to the cytoplasm, and is also involved in binding proteins to initiate translation.