Table of Contents
Is there a sliding scale for glargine?
Common sliding scale regimens: Long-acting insulin (glargine/detemir or NPH), once or twice a day with short acting insulin (aspart, glulisine, lispro, Regular) before meals and at bedtime.
What is basal dosing of insulin?
Approximately 40-50% of the total daily insulin dose is to replace insulin overnight, when you are fasting and between meals. This is called background or basal insulin replacement. The basal or background insulin dose usually is constant from day to day.
How do you titrate intermediate insulin?
Titrating Insulin Patients should titrate the dose 2 units at a time every two to three days, based on SMBG, until the FPG is at goal. A more aggressive starting dose for patients failing current therapy and an HbA1c above 8.5% would be 0.3 U/kg.
What is insulin action time?
Duration of insulin action (DIA) (or active insulin time) is how long a bolus of insulin takes to finish lowering blood glucose. The DIA time starts when a bolus is given and ends when the bolus is no longer lowering blood glucose levels.
What is pharmacokinetics of insulin?
The pharmacokinetics of insulin comprise the absorption process, the distribution including binding to circulating insulin antibodies, if present, and to insulin receptors, and its ultimate degradation and excretion. The distribution and metabolism of absorbed insulin follow that of endogenous insulin.
What is sliding scale insulin?
A sliding scale varies the dose of insulin based on blood glucose level. The higher your blood glucose the more insulin you take. The Sliding Scale method is more precise than fixed dose insulin in that it takes account of the fact that people’s blood glucose is not always in the normal range before meals.
When do you start sliding scale insulin?
Indications for VRIII (sliding scale) Patients with type 1 diabetes who are unable to eat and drink. Patients with type 1 diabetes with recurrent vomiting (exclude DKA) Patients with type 1 or 2 diabetes and severe illness with need to achieve good glycaemic control e.g. sepsis.
Does adocia own the rights to biochaperone lispro?
Adocia retains the rights to develop and commercialize BioChaperone Lispro and BioChaperone Combo in the US, Europe, Japan and Latin America. January 3rd 2019: Adocia Announces the first trial to test the ultra-rapid insulin BioChaperone Lispro using an autonomous insulin delivery system, namely Beta Bionics iLet TM.
Is sliding scale insulin effective for treating diabetes?
The American Diabetes Association (ADA) warn that using only sliding scale insulin for treatment is ineffective for most people. It can increase the risk of both high and low blood sugar and of complications if the person needs surgery. Most doctors advise against using this approach.
What is the ultra-rapid insulin analog lispro?
To address the need for an ultra-rapid insulin, Adocia has developed two ultra-rapid formulations of insulin analog lispro: BioChaperone® Lispro U100 (standard insulin concentration: 100 IU/mL) and BioChaperone® Lispro U200 (twice as concentrated solution, i.e., 200 IU/mL, especially adapted to people with high insulin needs).
What are the potential benefits of accelerating prandial insulin?
The potential benefits of accelerating prandial insulin. An ultra-rapid insulin is an insulin that has a more rapid absorption profile than the rapid-acting insulin analogs currently on the market, aiming to mimic the immediate secretion of insulin when a non-diabetic person eats a meal.