Table of Contents
What is the drug CIMZIA used for?
CIMZIA is a prescription medicine called a Tumor Necrosis Factor (TNF) blocker used in adults to: Lessen the signs and symptoms of moderately to severely active Crohn’s disease (CD) in adults who have not been helped enough by usual treatments. Treat moderately to severely active rheumatoid arthritis (RA)
What does CIMZIA do to the body?
Certolizumab pegol is a drug that reduces the signs and symptoms of moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, and Crohn’s disease. It works to improve such symptoms as joint swelling, pain, fatigue, and morning stiffness.
Is CIMZIA better than Humira?
Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects. People taking Cimzia (certolizumab) for Crohn’s disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
Can CIMZIA work immediately?
37% of placebo patients; 40% and 49% of CIMZIA patients at 1-2 weeks vs. 16% and 28% of placebo patients, respectively. People taking CIMZIA had significant improvement in as fast as 12 weeks in daily activities such as: Bending from the waist to pick up items.
What should I know about certolizumab before taking it?
Individuals with active infections should not be treated with certolizumab. Certolizumab may worsen or cause new diseases of the nervous system. Certolizumab also may cause or worsen congestive heart failure. In studies, some patients who used certolizumab or other TNFα blocking drugs developed cancer.
What is certolizumab (Cimzia)?
Certolizumab (Cimzia) is an injectable protein antibody (man-made) that binds to the tumor necrosis factor alpha. Cimzia is prescribed for the treatment of rheumatoid arthritis and Crohn’s disease.
What is the molecular weight of certolizumab pegol?
The Fab’ fragment is composed of a light chain with 214 amino acids and a heavy chain with 229 amino acids. The molecular weight of certolizumab pegol is approximately 91 kiloDaltons. CIMZIA (certolizumab pegol) for injection is supplied as a sterile white, lyophilized powder in a single-dose vial for subcutaneous use.
How does certolizumab pegol work in patients with Crohn’s disease?
Certolizumab pegol binds to TNFα, inhibiting its role as a key mediator of inflammation. TNFα is strongly expressed in the bowel wall in areas involved by Crohn’s disease and fecal concentrations of TNFα in patients with Crohn’s disease have been shown to reflect clinical severity of the disease.