Is obinutuzumab immunotherapy or chemotherapy?
Obinutuzumab is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Obinutuzumab is classified as a “monoclonal antibody” (For more detail, see “How Obinutuzumab Works” section below).
What is obinutuzumab used for?
Descriptions. Obinutuzumab injection is used together with other medicines (eg, chlorambucil) to treat chronic lymphocytic leukemia (CLL). Obinutuzumab injection is also used together with bendamustine to treat follicular lymphoma after other medicines (eg, rituximab) did not work well.
Is obinutuzumab an immunosuppressant?
Vaccination with live virus vaccines is not recommended during treatment and until B-cell recovery because of the immunosuppressive effect of obinutuzumab (see section 4.4). The combination of obinutuzumab with chlorambucil, bendamustine, CHOP or CVP may increase the risk of neutropenia (see section 4.4).
Is chlorambucil still used?
The major uses are in the treatment of Waldenström macroglobulinemia, low-grade lymphomas, chronic lymphocytic leukemia (CLL), and Hodgkin lymphoma. Except for CLL, chlorambucil has been supplanted by newer agents.
Does obinutuzumab cause weight gain?
Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.
Does obinutuzumab cause hair loss?
You could lose all your hair. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Your hair will usually grow back once treatment has finished but it is likely to be softer. It may grow back a different colour or be curlier than before.
How often is obinutuzumab given?
GAZYVA is given for a total of 6 cycles, or rounds of treatment. Each cycle will last 28 days. Treatment occurs only on certain days of each cycle and that is usually followed by several weeks of rest and recovery. This means that most people will complete their GAZYVA treatment in about 6 months.
How effective is obinutuzumab?
This trial also showed that 75% of patients in the group who received obinutuzumab survived to the end of the study, compared with only 65% of the patients receiving chemotherapy alone; this represented a 33% lower risk of death in the group of patients who received obinutuzumab (Fig.
Is obinutuzumab an immunotherapy?
Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Which of the following is adverse effect of chlorambucil?
Chlorambucil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea. vomiting.
What are the side effects of chlorambucil?
Side effects may include fur loss, or a change in the hair coat, especially in certain breeds. Serious side effects include low energy/depression, lack of appetite, vomiting, diarrhea, abnormal bleeding, bruising, infection, shortness of breath, agitation, facial twitching, seizures, or bloody diarrhea.
Does obinutuzumab cause memory loss?
This medicine may increase your risk of developing a serious and rare brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you have vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, or weak legs.
Can I drink alcohol while taking obinutuzumab?
The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of obinutuzumab. pregnancy. It is best to use birth control while being treated with obinutuzumab and for 18 months after your last dose of obinutuzumab.
Does obinutuzumab cause shortness of breath?
Infusion reactions are common with this medication. This can cause difficulty breathing, chills, fever, flushing, low blood pressure, “racing” heart, and nausea and vomiting.
How long is obinutuzumab infusion?
Administer at 25 mg/hr over 4 hours. Do not increase the infusion rate.