What does SV40 T antigen do?
The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication, and alteration of the cell cycle.
Does SV40 cause human cancer?
A meta-analysis of molecular, pathological, and clinical data from 1,793 cancer patients indicates that there is a significant excess risk of SV40 associated with human primary brain cancers, primary bone cancers, malignant mesothelioma, and non-Hodgkin’s lymphoma.
How do you get simian virus?
Simian virus 40 (SV40) is a monkey virus which was accidentally administered to humans, in the years 1955-’63, through contaminated poliovirus vaccines.
Does SV40 cause mesothelioma?
demonstrated that SV40 and asbestos are co-carcinogens in causing mesothelioma in hamsters and malignant transformation of HM cells in tissue culture (56). This study strongly suggested that SV40 infection and asbestos exposure together could have contributed to the development of human mesothelioma.
Is SV40 a retrovirus?
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often persists as a latent infection….
How does SV40 promote cellular transformation?
SV40 LT binding proteins Mutations that render LT unable to bind to Rb or p53 disable its ability to transform primary rodent and human cells. In addition to Rb and p53, LT binds to several additional cellular proteins that contribute to its transforming potential.
What kind of virus is SV40?
Polio vaccines used in the late 1950s and early 1960s were contaminated with a virus called simian virus 40 (SV40) present in monkey kidney cells used to grow the vaccine.
What does the simian flu do to humans?
First, the virus has mutated, rendering the affected humans as mute. That gets us back to a similar place we saw in the original Planet of the Apes where humans couldn’t speak, and so War offers an explanation as to why. The other major change is that it turns out the virus that killed humans also made all apes smart.
What are the symptoms of the simian flu?
Simian B Virus Infection is characterized by fever, headache, vomiting, discomfort (malaise), and a stiff neck and back.
How is SV40 transmitted?
Recent molecular biology and epidemiological studies suggest that SV40 may be contagiously transmitted in humans by horizontal infection, independently from the earlier administration of SV40-contaminated vaccines.
What is the full name of virus SV40?
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often persists as a latent infection.
How does SV40 immortalization work?
SV40 Tag was found to bind and inactivate p53 and pRB, abrogating apoptotic mechanisms and control of cell proliferation, allowing cellular overgrowth and escape from senescence, and interestingly Tag-p53 complexes bind and activate the IGF-1 promoter, resulting in increased malignant cell growth [14, 15].
Why is it called the simian flu?
Simian B Virus Infection is caused by herpesvirus simiae (also known as B virus), a type of herpesvirus that is highly prevalent (i.e., enzootic) among macaque monkeys, i.e., certain Asiatic monkeys belonging to the “Macaca” genus.
What does simian flu do?
The Simian Flu is a genetically modified virus created in a Gen-Sys lab. It has been found to increase intelligence in apes, but mutates rapidly and is untested on humans… Experience Planet of the Apes on a global scale – See how humanity responds as you infect the world with a lethal, artificial virus.
Who discovered SV40?
SV40 was first identified by Ben Sweet and Maurice Hilleman in 1960 when they found that between 10 and 30% of polio vaccines in the USA were contaminated with SV40. In 1962, Bernice Eddy described the SV40 oncogenic function inducing sarcoma and ependymomas in hamsters inoculated with monkeys cells infected with SV40.