Table of Contents
Do endothelial cells express CD34?
CD34 is a cell surface marker that is expressed by a broad range of cells including hematopoietic, stromal, epithelial, and endothelial cells.
What is the role of CD34?
CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive.
Is CD34 expressed on T cells?
Normal human T-cell differentiation proceeds notably through acquisition or loss of surface markers, such as CD34 and CD7, the former marker being progressively lost as maturation progresses while CD7 expression persists and other markers such as CD1a, CD4, CD8 and CD3 appear.
Where is CD34 expressed?
CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell.
Are endothelial cells CD34 positive?
Capillaries of most tissues are CD34 positive, as are umbilical artery and, to a lesser extent, vein, but the endothelium of most large vessels and the endothelium of placental sinuses are not. Angioblastoma cells and parafollicular mesenchymal cells in fetal skin are also CD34 positive, as are some stromal elements.
Which cells are CD34+?
CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction. Clinical transplantation studies that used enriched CD34+ BM cells indicated the presence of HSC with long-term BM reconstitutional ability within this fraction.
What cells are CD34+?
CD34 is a transmembrane glycoprotein expressed on early lymphohematopoietic stem cells, progenitor cells, and endothelial cells. Also, embryonic fibroblasts and some cells in fetal and adult nervous tissue are CD34-positive.
What are CD34+ blasts?
Background: The stem cell marker CD34 is expressed by leukemia blasts only for a subset of patients with acute myelogenous leukemia (AML).
Is CD31 a marker for endothelial cells?
CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM-1), is thought to be a sensitive and specific marker for vascular differentiation. It is a transmembrane glycoprotein expressed by endothelial cells and a variety of hematopoietic cells.
Who is hematopoietic stem cell CD34+ or CD34?
Hematopoietic stem cells (HSC) possess multipotentiality, enabling them to self-renew and also to produce mature blood cells, such as erythrocytes, leukocytes, platelets, and lymphocytes. CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction.