Table of Contents
Where is FABP4 expressed?
adipocytes
FABP4 is highly expressed in adipocytes and consists of about 1% of all soluble proteins in adipose tissue. Expression of FABP4 is highly induced during adipocyte differentiation and transcriptionally controlled by peroxisome proliferator-activated receptor (PPAR) γ agonists, FAs, dexamethasone, and insulin.
What do fatty acid binding proteins do?
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes.
Is adiponectin a gene?
ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include Adiponectin, Serum Level Of, Quantitative Trait Locus 1 and Fatty Liver Disease. Among its related pathways are Adipogenesis and AMP-activated protein kinase (AMPK) signaling.
What causes adiponectin release?
Your adipose tissue (body fat) is mainly responsible for producing adiponectin, though other tissues in your body produce it as well. Hormones are chemicals that coordinate different functions in your body by carrying messages through your blood to your organs, muscles and other tissues.
Why do fatty acids bind to albumin?
Because of their low solubility in aqueous solutions such as blood plasma and interstitial fluid, fatty acids are in need of binding proteins to increase their concentration in vascular and interstitial compartments. Albumin acts as main fatty acid binding protein in extracellular fluids.
Does high zonulin mean leaky gut?
Only the tiniest particles should pass through. Zonulin makes the holes of the cheesecloth bigger and allows large particles to pass into the bloodstream and through the body. We call this increased intestinal permeability, or leaky gut.
What does it mean if you have high zonulin?
Zonulin is considered a biomarker of increased intestinal permeability, and elevated levels have been found in celiac disease.
What does the gene Fabp4 do?
Entrez Gene Summary for FABP4 Gene. FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
What does fabp4/ap2 stand for?
Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via upregulation of the uncoupling protein 2 (UCP2).
What are fatty acid binding proteins (FABPs)?
Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] See more… FABP4 encodes the fatty acid binding protein found in adipocytes.
Does ablation of fabp4/ap2 regulate redox capacity and redox oxidation?
Here, we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity and reduces cellular protein sulfhydryl oxidation and, in particular, oxidation of mitochondrial protein cysteine residues.