Table of Contents
What are common platelet disorders?
The most common types are:
- Bernard Soulier disease.
- Glanzmann’s thrombasthenia.
- Hermansky Pudlak syndrome.
- Jacobsen syndrome.
- Lowe syndrome.
- Platelet release and storage pool defects.
- Thrombocytopenia with absent radius (TAR) syndrome.
- Thrombotic thrombocytopenic purpura (TTP)
Is Pseudothrombocytopenia common?
Pseudothrombocytopenia is an uncommon and often unrecognised phenomenon that results in errors in the interpretation of platelet counts with consequent inappropriate clinical decisions or useless, and sometimes dangerous, therapeutic interventions.
What causes EDTA-induced pseudothrombocytopenia?
EDTA-induced pseudothrombocytopenia, the most frequently seen form in clinical practice, occurs mainly due to reaction of antiplatelet antibodies including cold agglutinin type of IgG, IgM and IgA with platelet surface antigens.
What is spurious thrombocytosis?
Spurious thrombocytosis is characterized by the presence of nonplatelet structures in the peripheral blood which are counted as platelets by the automated counters used in modern complete blood counts. A variety of such structures, including needle-like cryoglobulin crystals [8. C. V. Hutchinson, P.
How do you rule out pseudothrombocytopenia?
A microscopic examination can identify platelet clumping and repeat CBC tests using a different anticoagulant can affirm the diagnosis. A 57-year-old retired farmer with no personal or family history of bleeding was found to have thrombocytopenia on routine blood work.
What is May hegglin?
May-Hegglin Anomaly is a rare, inherited, blood platelet disorder characterized by abnormally large and misshapen platelets (giant platelets) and defects of the white blood cells known as leukocytes.
Is TTP the same as von Willebrand disease?
Thrombotic thrombocytopenic purpura (TTP) is a disorder with characteristic von Willebrand factor (VWF)-rich microthrombi affecting the arterioles and capillaries of multiple organs. The disorder frequently leads to early death unless the patients are treated with plasma exchange or infusion.
How do you rule out Pseudothrombocytopenia?
What causes spurious thrombocytopenia?
Pseudo-thrombocytopenia (PTCP), or spurious thrombocytopenia, is an in vitro specimen-collection problem that occurs when the anticoagulant used while testing the blood specimen causes clumping of platelets (PLTs), which results in spuriously low PLT counts.
What causes Job’s syndrome?
The rare immunodeficiency disorder known as Job’s syndrome is caused by a specific genetic mutation that both overstimulates and understimulates the human immune system, leading to harmful bacterial and fungal infections and the physical features characteristic of the syndrome, according to two independent groups of …