What are the brand names for SGLT2 inhibitors?
Currently there are three SGLT2 selective inhibitors approved by the Food and Drug Administration (FDA) for mono, dual, and triple therapy: canagliflozin (Invokana®), dapagliflozin (Farxiga®) and empagliflozin (Jardiance®) (5, 11, 12).
What are examples of SGLT2 inhibitors?
Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin. They are available as single-ingredient products and also in combination with other diabetes medicines such as metformin.
Which SGLT2 inhibitor is most effective?
Empagliflozin is a potent SGLT2 inhibitor used to improve glycemic control in adults with T2DM. It has the highest SGLT2 specificity among all the clinically used or currently tested SGLT2 inhibitors.
Is Januvia a SGLT2?
Invokana and Januvia work in two different ways: Invokana is classified as an SGLT-2 (sodium-glucose co-transporter-2) inhibitor and Januvia is an incretin-based therapy.
What is another name for dapagliflozin?
Brand names: Forxiga. Find out how dapaglifozin treats type 2 diabetes and heart failure, and how to take it.
What medications are SGLT1 inhibitors?
Table 1
| Compound | SGLT1 ICso (nmol/L) | References |
|---|---|---|
| Empagliflozin Jardiance® | ~8300 | 34,127 |
| Ertugliflozin Steglatro® | ~1960 | 34,128 |
| Luseogliflozin Lusefi® | ~4071 | 129,130 |
| Dapagliflozin Farxiga® | ~1400 | 131,132 |
What was the first SGLT2 inhibitor?
The first SGLT2 inhibitor to be FDA-approved was canagliflozin (marketed as Invokana®) in March 2013, followed by the approval of dapagliflozin (marketed as Farxiga®) in January 2014 and empagliflozin (marketed as Jardiance®) in August 2014.
Is dapagliflozin better than empagliflozin?
More specifically, empagliflozin was more effective in reducing HbA1c and improving other cardiometabolic parameters than dapagliflozin.
Is Jardiance better than Farxiga?
The key difference between these drugs lies in the type of heart disease complications they’re approved to help prevent. Jardiance is approved to reduce the risk of death from heart attacks, stroke, and heart failure. Farxiga, on the other hand, is approved to reduce the risk of hospitalization from heart failure.
Is Farxiga and Jardiance the same?
Is glimepiride a SGLT2 inhibitor?
Sulfonylureas, such as glimepiride, are often the next medication given. Sulfonylureas lower blood glucose by stimulating the release of insulin. However, they are associated with side effects like weight gain and hypoglycemia (dangerously low blood glucose). Empagliflozin is an SGLT2 inhibitor.
What is the generic name for Jardiance?
Generic Name: empagliflozin Empagliflozin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Are dapagliflozin and empagliflozin the same?
Jardiance contains the active drug empagliflozin. Farxiga contains the active drug dapagliflozin. These drugs belong to the same class of medications: sodium-glucose co-transporter 2 (SGLT2) inhibitors. They work by making your kidneys remove more sugar from your blood and eliminate it from your body in your urine.
Is januvia a SGLT2 inhibitor?
Is Januvia a SGLT2 inhibitor?
How many types of Gliptins are there?
There are at least seven different classes of agents used as monotherapy, or in combinations for the treatment of diabetes mellitus. These include metformin, sulphonylureas, meglinitides, alpha-glucosidase inhibitors, thiazolidinediones (TZD), glucagon like peptide-1 (GLP-1) agonists and insulin[1,2].