Table of Contents
What cells express PDPN?
Lymphatic endothelial cells and FRCs, the two major subsets of lymphoid stromal cells, express high levels of PDPN (Malhotra et al., 2012; Table 1), but only a few studies have examined the molecular function of PDPN in these cells.
What is Podoplanin?
In particular, PDPN increases tumor cell clonal capacity, epithelial mesenchymal transition, migration, invasion, metastasis and inflammation. Antibodies, CAR‐T cells, biologics and synthetic compounds that target PDPN can inhibit cancer progression and septic inflammation in preclinical models.
Do fibroblasts express Podoplanin?
It was shown that podoplanin present on the surface of fibroblasts does not directly affect the malignant properties of breast cancer cells, but increases their motility, facilitating in this way the movement of fibroblasts into tumor stroma.
What are lymphatic endothelial cells?
Lymphatic endothelial cells (LECs) form the structure of the lymphatic vessels and the sinuses of the lymph nodes, positioning them to be key players in many different aspects of the immune response. Following an inflammatory stimulus, LECs produce chemokines that recruit immune cells to the lymph nodes.
What does Podoplanin stain for?
Membranous podoplanin staining has been proposed as a specific and sensitive marker to distinguish epithelioid mesothelioma from adenocarcinoma. We found that cytoplasmic podoplanin staining was present in sarcomatoid mesotheliomas, and wanted to explore the reproducibility and specificity of this staining pattern.
Where are lymphatic endothelial cells located?
the lymph nodes
Lymphatic endothelial cells (LECs) form the structure of the lymphatic vessels and the sinuses of the lymph nodes, positioning them to be key players in many different aspects of the immune response. Following an inflammatory stimulus, LECs produce chemokines that recruit immune cells to the lymph nodes.
Does lymphatics have endothelium?
Structure–function relationships of the lymphatic capillary Lymphatic capillaries are blind-ending vessels, comprised of a single, nonfenestrated endothelial cell layer, that is optimally adapted for the uptake of fluid, macromolecules, and cells.
What WT1 positive?
WT1-positive tumors included tumor of the stomach, prostate, and biliary and urinary systems, and malignant melanomas. A majority of the positive cases showed diffuse or granular staining in the cytoplasm, whereas ovarian tumors and desmoplastic small round cell tumors frequently showed nuclear staining.
What does cytokeratin positive mean?
Cytokeratin 5/6 is a positive marker for malignant pleural mesothelioma, found in more than three-fourths of cases. It is also found in certain types of lung cancers and breast cancers. Pathologists use cytokeratin 5/6 to stain cancer tissue samples.
What are vascular endothelial cells?
The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner cellular lining of arteries, veins and capillaries and therefore is in direct contact with the components and cells of blood. The endothelium is not only a mere barrier between blood and tissues but also an endocrine organ.
What is a WT1 marker?
Aims: Wilms tumor protein 1 (WT1) expression is used in gynecological pathology as a diagnostic marker of serous differentiation, and is frequently co-expressed with ER-α. Early phase studies on WT1 vaccine in gynecological cancers are ongoing.
What does WT1 gene do?
The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 protein activity is limited to a structure known as the glomerulus, which filters blood through the kidneys.
What does CK7 positive mean?
For the CK7 negative group, no tumor cells yielded positive IHC staining results for CK7. For the CK7 positive group, diffuse or focal CK7 positive tumor cells were present in tumor tissue. The diffuse distribution of CK7 positive tumor cells was often present in poorly differentiated CRCs.
What does PDPN stand for?
Podoplanin is a protein that in humans is encoded by the “PDPN” gene. Podoplanin is a mucin -type protein with a mass of 36- to 43-kDa.
What is the PDPN gene?
PDPN (Podoplanin) is a Protein Coding gene. Diseases associated with PDPN include Lymphangioma and Angiosarcoma . Among its related pathways are Cytoskeletal Signaling and Response to elevated platelet cytosolic Ca2+ .
What type of protein is podoplanin?
Podoplanin is a mucin -type protein with a mass of 36- to 43-kDa. It is relatively well conserved between species, with homologues in humans, mice, rats, dogs and hamsters. This gene encodes a type-I, integral membrane, heavily O- glycosylated glycoprotein with diverse distribution in human tissues.
What is included in the gene tree for PDPN?
Gene Tree for PDPN (if available) Gene Tree for PDPN (if available) All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream). PDPN PDPN No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDPN Gene