Table of Contents
What does NKX2 5 stand for?
NKX2-5 is a transcription factor that regulates heart development from the Cardiac Crescent of the splanchnic mesoderm in humans. NKX2-5 is dependent upon the JAK-STAT pathway and works along with MEF2, HAND1, and HAND2 transcription factors to direct heart looping during early heart development.
Do plants have Hox genes?
However, the Hox gene family is part of an even larger family called the homeobox genes, which are found in almost all eukaryotes — including at least 10 classes of plants.
What organisms have Hox genes?
The Hox genes, being a subset of homeobox genes, arose more recently in evolution within the animal kingdom or Metazoa. Within the animal kingdom, Hox genes are present across the bilateria (animals with a clear head-to-tail axis), and have also been found in Cnidaria such as sea anemones.
How many Hox genes do humans have?
39 human HOX genes
The 39 human HOX genes are located in four clusters (A-D) on different chromosomes at 7p15, 17q21. 2, 12q13, and 2q31 respectively and are assumed to have arisen by duplication and divergence from a primordial homeobox gene.
What is Acrocallosal syndrome?
Acrocallosal syndrome is a rare condition characterized by a brain abnormality called agenesis of the corpus callosum, the presence of extra fingers and toes (polydactyly), and distinctive facial features.
What is the function of NKX2 5?
NKX2-5 is a transcription factor that regulates heart development from the Cardiac Crescent of the splanchnic mesoderm in humans. NKX2-5 is dependent upon the JAK-STAT pathway and works along with MEF2, HAND1, and HAND2 transcription factors to direct heart looping during early heart development.
Is NKX2-5 a cytotoxic agent in the heart?
This finding suggests that NKX2-5 is implicated in cardiac injury via cytotoxic effects. During embryogenesis, NKX2-5 is expressed in early cardiac mesoderm cells throughout the left ventricle and atrial chambers.
What is the interaction between NKX2-5 and Tbx5?
NKX2-5 has been shown to interact with GATA4 and TBX5. NKX2-5 is a transcription factor that regulates heart development from the Cardiac Crescent of the splanchnic mesoderm in humans.
Where is NKX2 expressed in the heart?
In the heart, NKX2.5 is first expressed in the cardiomyogenic progenitor cells during the formation of the lateral plate mesoderm in the late gastrula. NKX2.5 is temporally downregulated during differentiation of cardiomyocytes and then expressed at lower levels in the myocardium throughout the live of an organism.