Table of Contents
What does CD38 bright mean?
Bright CD38 Expression by Flow Cytometric Analysis Is a Biomarker for Double/Triple Hit Lymphomas with a Moderate Sensitivity and High Specificity.
What cells are CD38 expressed on?
CD38 is expressed in many immune cell types, including bone marrow progenitors, natural killer cells, monocytes, and activated T- and B- lymphocytes [6].
What is CD38 function?
CD38 is type II membrane glycoprotein that plays a role in cell adhesion, migration, and signal transduction. Additionally, CD38 is an ectoenzyme involved in generation of nucleotide metabolites, such as ADP-Ribose (Lee, 2006). CD38 expression is highly upregulated on human plasma cells and especially on MM cells.
Is CLL CD10 positive?
Results: CD10 positive cells were absent in B-CLL cell suspensions, but were detected following in vitro culture, and their appearance paralleled that of apoptotic cells. Treatment with etoposide, fludarabine or Ga(mu)-Ab enhanced both apoptosis and CD10 expression.
What are CD38 positive cells?
The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.
Why does CD38 increase?
# CD38 levels increase in tissues with age, and correlate with NAD decline. # NAD and mitochondrial function are preserved in old CD38 knockout mice. # CD38 metabolizes NMN in vivo and the response to NAD-replacement therapy.
What does CD10 positive mean?
The CD10 positive stromal cells are present at the cancer cells invasive front suggests the interaction between breast cancer cells and CD10-positive stromal cells. Moreover, presence of CD10 on stromal cells positively correlates with nodal metastasis, tumor grade, tumor size, lymph node and worsening prognosis.
What is CD10 positive B cell lymphoma?
Background and objectives: CD10 is a proteolytic enzyme expressed on the surface of germinal center cells and lymphomas derived from these cells. There is a well-known association between CD10 expression and lymphomas of follicular center cell origin.
What is a CD38 antibody?
A substance that binds to a protein called CD38, which is found on some types of blood cells and in high levels on some cancer cells, including myeloma cells. Anti-CD38 monoclonal antibody may block the CD38 protein and help the immune system kill cancer cells.
What is CD38 negative?
Comparison of CD38+ and CD38− patient subgroups Patients with 20% or more B cells expressing CD38 were considered positive, and those with less than 20% were considered negative.
What is GL7 marker?
GL7 is commonly used as a marker for mouse germinal center B cells. The epitope of GL7 has been identified as a sialic acid glycan moiety called Neu5Ac. This moiety is recognized by CD22.
What does GL-9 mean?
GL-9. Qualifying Experience. Or Graduate Education. Or Combination of Experience and Education. Or Superior Academic Achievement (SAA)
Whats the difference between GL 7 and GL 9?
The GL-9 level, which pertains to a rank and pay scale higher than the GL-5 and GL-7 levels, does not look into educational qualifications. However, it requires that applicants have at least a year’s worth of experience in the law enforcement field.
What percentage of CLL patients are CD38 positive?
Based on a cut-off value of 20%, CLL patients were categorised into a CD38-positive (> or = 20%, n = 56) and a CD38-negative subgroup (< 20%, n = 77) an … CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia Leukemia. 2002 Jan;16(1):30-5.doi: 10.1038/sj.leu.2402339. Authors
Is CD38 a marker of progressive disease in chronic lymphocytic leukemia?
1 Department of Clinical Haematology, national Medical Center, Budapest, Hungary. [email protected] Cell-surface expression of CD38 in CLL has been recognised recently as a marker of progressive disease and poor outcome. In contrast to traditional staging systems, CD38 is able to identify progressive cases at an early stage.
What is the prognosis of B-CLL with high CD38 expression?
In this study, we found that patients with B-CLL could be divided into 2 prognostically different groups—those with worse prognoses had high CD38 expression on malignant cells (20% or more), and those with a good prognoses had low CD38 expression (less than 20%).
What is the relationship between CD38 and clinical parameters?
Although CD38 expression was constant (negative or positive) over a variable period of time in 6 of 7 patients examined, it increased significantly in 1 patient (9% to 89%). This increase in CD38 expression was associated with marked worsening of the patient’s clinical parameters.