Table of Contents
What is bioadhesive microsphere?
Bioadhesive microspheres include microparticles and microcapsules (having a core of the drug) of 1–1000 μm in diameter and consisting either entirely of a bioadhesive polymer or having an outer coating of it, respectively (Mathiowitz et al., 2001).
What are microspheres in medicine?
Microspheres are polymeric micron range particles with sizes from 1 to 1000 µm (Table 10.1). These microspheres are used for drug delivery, wherein the drug can be encapsulated or entrapped form. Based on the polymeric composition of microspheres, they can be classified into two types: natural and synthetic.
Which method is used for preparation of microspheres?
[6] Chitosan microspheres have been prepared by emulsion crosslinking, ion-induced coagulation, and spray-drying methods. Of these methods, the most common method used to prepare chitosan microspheres is the emulsion chemical crosslinking method.
What is magnetic microsphere?
Magnetic microspheres are supramolecular particles that are small enough to circulate through capillaries without producing embolic occlusion (<4μm)but are sufficiently susceptible (ferromagnetic) to be captured in micro-vessels and dragged into the adjacent tissues by magnetic field of 0.5-0.8 tesla [1,2].
What is bioadhesive polymer?
Bioadhesives are natural polymeric materials that act as adhesives. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean a synthetic material designed to adhere to biological tissue.
Is an example of bioadhesive polymer?
Based on their properties, the specific bioadhesive polymers (e.g., lectins, and fimbrins) have the ability to adhere to specific chemical structures within the biological molecules while the nonspecific bioadhesive polymers (e.g., polyacrylic acid [PAA] and cyanoacrylates) have the ability to bind with both the cell …
What are microspheres made of?
Microsphere are made from glass, ceramic, carbon or plastic depending on applications. Solid glass microsphere is manufactured by direct burning of glass powders while hollow glass microspheres is produced by adding blowing agent to glass powder.
What is chitosan microspheres?
Chitosan microspheres are used to provide controlled release of many drugs and to improve the bioavailability of degradable substances such as protein or enhance the uptake of hydrophilic substances across the epithelial layers. These microspheres are being investigated both for parenteral and oral drug delivery.
What does bioadhesive mean?
Medical Definition of bioadhesive : tending to adhere to or cause adhesion in living tissue bioadhesive gels Encapsulating the drug in a bioadhesive polymer means that the capsule stays in the GI tract longer, allowing more drug molecules to diffuse from it and be absorbed through the intestinal walls.—
What is bioadhesive drug delivery?
Bioadhesive systems provide intimate contact between a dosage form and the absorbing tissue, which may result in high concentration in a local area and hence high drug flux through the absorbing tissue.
What are bioadhesive tablets?
Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal candidiasis.
What is bioadhesive property?