What therapies are most appropriate for the treatment of malaria?
Artemether-lumefantrine (Coartem™) is the preferred follow-on treatment but adequate alternatives are atovaquone-proguanil (Malarone™), quinine plus doxycycline or clindamycin, or mefloquine.
What is used for presumptive treatment of malaria?
Plasmodium falciparum In “High Risk Areas”, fever cases are given presumptive treatment with 1500 mg Chloroquine (over 3 days) and 45 mg Primaquine (adult single dose).
What is the first-line treatment of malaria?
As of April 2019, artesunate, the WHO-recommended first-line treatment of severe malaria, will become the first-line treatment for severe malaria in the U.S. Malaria has long been a major cause of illness and deaths with an estimated 219 million cases of malaria worldwide and 435,000 deaths in 2017.
What is the meaning of ACT drugs?
Abstract. Artemisinin-based combination therapies (ACTs) are the best anti-malarial drugs available now. Artemisinin enhances efficacy and has the potential of lowering the rate at which resistance emerges and spreads.
What is presumptive therapy?
Presumptive treatment is defined as one-time treatment for a presumed infection in a person, or a group of people, at high risk of infection. Presumptive treatment for STIs is often given at repeated intervals, in which case it is known as periodic presumptive treatment.
Is artesunate an act?
Four ACTs are currently recommended by WHO: artesunate–mefloquine, artesunate–sulfadoxine–pyrimethamine (SP), artesunate–amodiaquine, and artemether–lumefantrine.
What is an example of ACT?
An act is defined as an action or something which is done. Drawing, eating and pretending you are someone else are all examples of an act. The definition of act means to do something. To sing, to dance and to swim are each an example of to act.
How do you inject artemether?
How do you inject Artemether? Artemether is delivered by intramuscular injection into the anterior thigh, diluted in oil (groundnut, sesame seed). Therapeutic dosage: Artemether’s initial dose is 3.2 mg/kg BW intramuscularly (to the anterior thigh). The intramuscular maintenance dosage is 1.6 mg/kg BW daily.
When do you give artesunate in malaria?
Per WHO guidelines, 3 doses of IV artesunate, administered intravenously over 1–2 minutes, at 12-hour intervals (0, 12, and 24 hours) is recommended for treatment of severe malaria. The dosing of IV artesunate is: 2.4 mg/kg at 0, 12, and 24 hours and can be continued daily for up to a total of 7 days, if needed.
What is meant by empirical treatment?
Empiric therapy or empirical therapy is medical treatment or therapy based on experience and, more specifically, therapy begun on the basis of a clinical “educated guess” in the absence of complete or perfect information.
What is presumptive evidence of infection?
of or relating to a positive test for a disease or medical condition that was done in a local laboratory, but whose results have not been officially confirmed by a public health agency or organization.