Table of Contents
How do you administer micafungin?
Administer MYCAMINE by intravenous infusion only. Infuse over one hour. More rapid infusions may result in more frequent histamine-mediated reactions [see WARNINGS AND PRECAUTIONS]. Flush an existing intravenous line with 0.9% Sodium Chloride Injection, USP, prior to infusion of MYCAMINE.
How do you reconstitute micafungin?
Reconstitution: MYCAMINE 50 mg vial: Aseptically add 5 mL of 0.9% Sodium Chloride Injection, USP (without a bacteriostatic agent) to each 50 mg vial to yield a preparation containing approximately 10 mg micafungin/mL. Dissolution: To minimize excessive foaming, GENTLY dissolve the MYCAMINE powder by swirling the vial.
Does micafungin need renal adjustment?
There are currently insufficient data available for the use of micafungin in patients with severe hepatic impairment and its use is not recommended in these patients (see sections 4.4 and 5.2). Renal impairment No dose adjustment is necessary in patients with renal impairment (see section 5.2).
Is micafungin removed by dialysis?
Being highly (> 90%) protein-bound, echinocandins are unlikely to be removed by hemodialysis or hemofiltration through convection. Standard dosing thus is considered to be appropriate during CRRT. However, drug adsorption on the filter membrane should not be underestimated.
What is micafungin used for?
Micafungin injection is used to help the body overcome serious fungus infections, such as candidemia, acute disseminated candidiasis, candida peritonitis and abscess without meningoencephalitis or ocular dissemination, and esophageal candidiasis.
What is the cost of micafungin?
The cost for micafungin intravenous powder for injection 100 mg is around $162 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Is micafungin compatible with meropenem?
Interactions between your drugs No interactions were found between meropenem and Mycamine.
Can you run potassium and magnesium together IV?
Intravenous administration of magnesium and potassium solution lowers energy levels and increases success rates electrically cardioverting atrial fibrillation. J Cardiovasc Electrophysiol.
Does potassium or MAG run first?
Within the context of electrolyte disturbances, magnesium replacement is often necessary before hypokalemia and potassium depletion can be satisfactorily corrected with potassium supplements.
Do you administer magnesium or potassium first?
Potassium repletion Always check the serum magnesium level and replete magnesium prior to repleting potassium. Low magnesium can exacerbate renal potassium losses.
Is potassium compatible with LR?
Potassium Chloride in Lactated Ringer’s and 5% Dextrose Injection, USP should not be administered simultaneously with blood through the same administration set because of the likelihood of coagulation.
Can you Y site heparin and normal saline?
It is concluded that heparin may be given intravenously in normal saline with benzylpenicillin, ampicillin, or methicillin but several other antibiotics were found to be unsuitable for concurrent infusion with heparin.
Can you give Mag and potassium at the same time?
Magnesium administration, concomitant with potassium, assists tissue replenishment of potassium. Therefore, we hypothesized that combinations of these cations would lower blood pressure.
How many mg of micafungin can you take in a day?
The doses of Micafungin for injection administered included doses above and below the recommended doses [see Dosage and Administration ( 2.1, 2.2 )] and ranged from 0.75 mg/kg to 10 mg/kg in pediatric patients and 12.5 mg to 150 mg/day or greater in adults.
What is the recommended dose of micafungin for the treatment of CVVH?
A loading dose of 150 mg is required to achieve the PK/PD target for less susceptible Candida species from the first day of therapy. No difference was observed in micafungin PK between equidoses of CVVH and CVVHDF.
How much micafungin is required to achieve the PK/PD target for Candida infection?
A loading dose of 150 mg is required to achieve the PK/PD target for less susceptible Candida species from the first day of therapy. No difference was observed in micafungin PK between equidoses of CVVH and CVVHDF. A loading dose of 150 mg is required to achieve the PK/PD target for less susceptible Candida species from the first day of therapy.
How is micafungin administered to adults with renal impairment?
A single 1-hour infusion of 100 mg Micafungin for injection was administered to 9 adult subjects with severe renal impairment (creatinine clearance less than 30 mL/min) and to 9 age-, gender-, and weight-matched subjects with normal renal function (creatinine clearance greater than 80 mL/min).