What does Aurka do?
AURKA is involved in the regulation of spindle-associated events during early mitosis. Many of the substrates regulated by AURKA coordinate with AURKA to control mitotic progression, and aberrant expression of AURKA in a variety of human cancers has been linked with mitotic defects.
What does APC Cdc20 do?
Once active, APC/CCdc20 promotes the degradation of Cdks by inactivating S/M cyclins. Cdk degradation brings about lower rates of APC/C phosphorylation and thus lower rates of CDC20 binding. In this way, the APC/CCdc20 complex inactivates itself by the end of mitosis.
What does Aurora A do?
Aurora A regulates mitotic entry through phosphorylation of CDC25B phosphatase (3) or PLK1 kinase (4, 5). Aurora A also contributes to DNA damage (6) and to spindle assembly checkpoints (SAC) (7). Once the cell is engaged into mitosis, Aurora A participates in mitotic spindle assembly and functioning.
Is Alisertib FDA approved?
The study drug, alisertib, is an investigational drug. An investigational drug is one that has not been approved by the U.S. Food and Drug Administration (FDA).
How do I activate my Cdk?
Cdk activation requires two steps. First, cyclin must bind to the Cdk. In the second step, CAK must phosphorylate the cyclin-Cdk complex on the threonine residue 160, which is located in the Cdk activation segment.
What is Wee1 inhibitor?
Introduction. WEE1 kinase is a serine-threonine kinase that regulates G2/M checkpoint transition [1–3]. WEE1 triggers G2/M arrest through inhibitory phosphorylation on Tyr15 of CDK1 (Cdc2) and preventing entry into mitosis to allow DNA repair during DNA damage [1–3].
What phase does cell size increase?
During G 1start subscript, 1, end subscript phase, also called the first gap phase, the cell grows physically larger, copies organelles, and makes the molecular building blocks it will need in later steps.
What happens in DNA?
How is DNA replicated? Replication occurs in three major steps: the opening of the double helix and separation of the DNA strands, the priming of the template strand, and the assembly of the new DNA segment. During separation, the two strands of the DNA double helix uncoil at a specific location called the origin.