Table of Contents
What is hepatocyte vacuolation?
Hepatocyte nuclear vacuolation is a marker of senescence. It is present in a variety of chronic liver diseases and is not restricted to non-alcoholic fatty liver disease. The pathophysiology behind the development of hepatocyte nuclear vacuolation is unclear.
What is cytoplasmic vacuolization?
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds.
What is hepatocyte cytoplasm?
Hepatocytes display an eosinophilic cytoplasm, reflecting numerous mitochondria, and basophilic stippling due to large amounts of smooth endoplasmic reticulum and free ribosomes.
Do hepatocytes have vacuoles?
The space of Disse is the narrow region located between endothelial cells and hepatocytes. These cells are identified histologically by their large lipid vacuoles.
What is Vacuolation in biology?
A vacuole is a membrane bound structure found in the cytoplasmic matrix of a cell. The membrane surrounding the vacuole is known as tonoplast. The components of the vacuole, known as the cell sap, differ from that of the surrounding cytoplasm. The membranes are composed of phospholipids.
What is the meaning of Vacuolated?
Definition of vacuolated : containing one or more vacuoles vacuolated epithelial cells.
Which organelles may be particularly common in the cytoplasm of hepatocytes?
Being one of the most metabolically active cells in the body, the hepatocyte is rich in organelles, the most abundant of which are the endoplasmic reticulum, mitochondria, peroxisomes, and lysosomes (see Fig. 1.24).
What is the color of the cytoplasm of the liver cell?
False colour transmission electron micrograph showing mitochondria (blue), glycogen (pink), and rough endoplasmic reticulum (red) in the cytoplasm of a hepatocyte (liver cell). Liver cells, or hepatocytes, have direct access to the liver’s blood supply through small capillaries called sinusoids.
Do liver cells have cytoplasm?
The liver cells containing the structure of their active period present a normal nucleus, glycogen granules disseminated throughout the entire cytoplasm and granular mitochondria with several peripheral cristae.
What are Vacuolated neutrophils?
Toxic vacuolation, also known as toxic vacuolization, is the formation of vacuoles in the cytoplasm of neutrophils in response to severe infections or inflammatory conditions.
What is recanalization?
Recanalization is the reestablishment of blood flow into a formerly occluded region (Hall et al., 1989). This phenomenon destabilizes the occluded region and may lead to significant rebleeding at the treatment site.
What organelles are found in liver cells?
The two main cell organelles of the liver, the mitochondria and the endoplasmic reticulum, comprise about 80% of the total liver protein. Of the approximately 150 mg of protein per g of liver, there are about 70 mg of mitochondrial and 55 mg of microsomal protein (1).
What organelles are found in hepatocytes?
What organelles are most abundant in the cytoplasm of hepatocytes?
What is the Colour of the cytoplasm of the liver cell?
What are the cytoplasmic organelles?
Cytoplasmic organelles are “little organs” that are suspended in the cytoplasm of the cell. Each type of organelle has a definite structure and a specific role in the function of the cell. Examples of cytoplasmic organelles are mitochondrion, ribosomes, endoplasmic reticulum, golgi apparatus, and lysosomes.
What is anisocytosis and Poikilocytosis?
The term anisopoikilocytosis is actually made up of two different terms: anisocytosis and poikilocytosis. Anisocytosis means that there are red blood cells of varying sizes on your blood smear. Poikilocytosis means that there are red blood cells of varying shapes on your blood smear.
What is cytoplasmic vacuolization in hepatitis A?
Cytoplasmic vacuolization of hepatocytes and ductal epithelial cells is a common finding in acute hepatitis A [295, 296]. Vacuolization as well as other cytopathic changes such as multilayer membrane structures and tubular-vesicular network are observed in HAV-infected cells in vitro[223, 297].
What is the pathophysiology of nonlipid cytoplasmic vacuolation of diffusely distributed hepatocytes?
Swelling with nonlipid cytoplasmic vacuolation of diffusely distributed hepatocytes is seen consistently after mild acute and subacute liver injury. Several lines of evidence point to the possibility that this change may reflect a cellular adaptation beneficial to the host, rather than a degenerative change.
What are the cytoplasmic vacuoles of liver cancer?
The cytoplasmic vacuoles contain plasma that has entered the hepatocyte cytoplasm (plasma influx) of affected hepatocytes (Li et al. 2003). Similar but more discrete eosinophilic hyalinized inclusions, which may represent protein present in lysosomes, can be seen in control and treated rodents and are also seen in hepatocellular neoplasms.
What causes cytoplasm to swell in hepatitis?
Swelling of hepatocytes with nonlipid vacuolation of the cytoplasm is frequently seen in acute liver injury induced by hepatitis viruses and a variety of hepatotoxic agents. This morphological change has conventionally been at- tributed to alterations in the injured cell as a result of hy- dropic change.