Table of Contents
What is normal retic index?
The reticulocyte index (RI) should be between 0.5% and 2.5% for a healthy individual. RI < 2% with anemia indicates maturation disorder, meaning loss of red blood cells, but also decreased production of reticulocytes (i.e., an inadequate response to correct the anemia) and therefore red blood cells.
What is a high reticulocyte index?
A higher than normal reticulocytes count may indicate: Anemia due to red blood cells being destroyed earlier than normal (hemolytic anemia) Bleeding. Blood disorder in a fetus or newborn (erythroblastosis fetalis) Kidney disease, with increased production of a hormone called erythropoietin.
What does reticulocyte index indicate?
A reticulocyte count measures the number of immature red blood cells (reticulocytes) in your bone marrow. Doctors measure reticulocytes to find out if your bone marrow is producing enough red blood cells.
What causes increased reticulocyte count?
The reticulocyte count rises when there is a lot of blood loss or in certain diseases in which red blood cells are destroyed prematurely, such as hemolytic anemia. Also, being at high altitudes may cause reticulocyte counts to rise, to help you adjust to the lower oxygen levels at high altitudes.
Is a high reticulocyte count serious?
A reticulocyte count (retic count) measures the number of reticulocytes in the blood. If the count is too high or too low, it can mean a serious health problem, including anemia and disorders of the bone marrow, liver, and kidneys.
What happens if reticulocyte count is high?
A higher than normal reticulocytes count may indicate: Anemia due to red blood cells being destroyed earlier than normal ( hemolytic anemia ) Bleeding. Blood disorder in a fetus or newborn (erythroblastosis fetalis)
What does low retic HGB mean?
The most common causes of low RETIC-HGB are blood loss and inflammatory disease, which both lead to decreased iron availability for RBC production. A low RETIC-HGB result may indicate serious underlying disease before an increase in RETICs or anemia, warranting further exploration.
What is the clinical significant of reticulocyte count?
How to calculate reticulocyte index?
■ By 1st approach: Let’s take the example of a person with a reti. count = 3.5% and a Hematocrit value of 30%, the RPI value is = Reticulocyte count x Hematocrit / Normal Hematocrit / Maturation correction = 3.5 x 30 / 45 / 1.5 The result displayed will be: – Reticulocyte Production Index (RPI) is 1.56.
How do you calculate reticulocyte production index?
– The Maturation term represents the maturation time of RBC’s (in days) at various levels of anemia. – Maturation = 1.0 for Hct ≥40%. – Maturation = 1.5 for Hct 30-39.9%. – Maturation = 2.0 for Hct 20-29.9%. – Maturation = 2.5 for Hct <20%. – An RPI >3 shows a normal marrow response to anemia. – With a normal H&H, an RPI of 1 is normal.
What causes high retic count?
A blood transfusion that was carried out less than three months before the reticulocyte count can affect the results.
How to calculate retic absolute?
– One week = 1.8 to 4.6% – One month = 0.1 to 1.7% – 6 months = 0.7 to 2.3% – >6 months = 0.5 to 1.0%